A scaffold for promoting cartilage formation is provided that includes a crosslinked electrospun fiber, wherein the crosslinked electrospun fiber consists essentially of crosslinked gelatin. The crosslinked electrospun fiber is generally crosslinked with a crosslinker, and the crosslinker may be diisosorbide bisepoxide. The crosslinked electrospun fiber may be crosslinked by adding a crosslinker to a solution of gelatin at a desired concentration. The electrospun fiber may advantageously remain intact for 18 days or longer upon being immersed in an aqueous solution. A composition for promoting cartilage formation is also provided that includes the disclosed scaffold and a mesenchymal stem cell (MSC). The disclosed scaffold may include a crosslinked electrospun fiber that includes gelatin and sodium cellulose sulfate (NaCS), e.g., in an amount of up to 5% by weight of the amount of gelatin. A method for promoting cartilage formation is also provided that includes administering to a subject in need thereof a disclosed composition for promoting cartilage formation in the subject.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Provided in the present application is a preparation method for a double-layer osteochondral tissue repair stent, comprising: formulating a first feed solution, the first feed solution comprising recombinant collagen, sodium hyaluronate, and hydroxyapatite; formulating a second feed solution, the second feed solution comprising recombinant collagen and sodium hyaluronate; freeze-drying the first feed solution and the second feed solution and forming a gel-like double-layer structure; and adding the gel-like double-layer structure into a crosslinking agent for crosslinking. The present method also relates to a double-layer osteochondral tissue repair stent, comprising: a first layer composed of raw materials including recombinant collagen, sodium hyaluronate, and hydroxyapatite; and a second layer composed of raw materials including recombinant collagen and sodium hyaluronate. The double-layer osteochondral tissue repair stent prepared by the present application has excellent mechanical properties, good biocompatibility, and a suitable degradation rate and, after degradation, the stent material can be reused as raw material for the formation of new bone, thus implementing osteochondral tissue repair.

Provided in the present application is a preparation method for a double-layer osteochondral tissue repair stent, comprising: formulating a first feed solution, the first feed solution comprising recombinant collagen, sodium hyaluronate, and hydroxyapatite; formulating a second feed solution, the second feed solution comprising recombinant collagen and sodium hyaluronate; freeze-drying the first feed solution and the second feed solution and forming a gel-like double-layer structure; and adding the gel-like double-layer structure into a crosslinking agent for crosslinking. The present method also relates to a double-layer osteochondral tissue repair stent, comprising: a first layer composed of raw materials including recombinant collagen, sodium hyaluronate, and hydroxyapatite; and a second layer composed of raw materials including recombinant collagen and sodium hyaluronate. The double-layer osteochondral tissue repair stent prepared by the present application has excellent mechanical properties, good biocompatibility, and a suitable degradation rate and, after degradation, the stent material can be reused as raw material for the formation of new bone, thus implementing osteochondral tissue repair.

Provided in the present application is a preparation method for a double-layer osteochondral tissue repair stent, comprising: formulating a first feed solution, the first feed solution comprising recombinant collagen, sodium hyaluronate, and hydroxyapatite; formulating a second feed solution, the second feed solution comprising recombinant collagen and sodium hyaluronate; freeze-drying the first feed solution and the second feed solution and forming a gel-like double-layer structure; and adding the gel-like double-layer structure into a crosslinking agent for crosslinking. The present method also relates to a double-layer osteochondral tissue repair stent, comprising: a first layer composed of raw materials including recombinant collagen, sodium hyaluronate, and hydroxyapatite; and a second layer composed of raw materials including recombinant collagen and sodium hyaluronate. The double-layer osteochondral tissue repair stent prepared by the present application has excellent mechanical properties, good biocompatibility, and a suitable degradation rate and, after degradation, the stent material can be reused as raw material for the formation of new bone, thus implementing osteochondral tissue repair.

The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.

Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.

Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.