A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.

A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.

The present invention relates to a fibrous nerve conduit for promoting nerve regeneration, comprising a channel, the channel having diameter controllable ends, the channel is adjustable to suturing to a proximal and distal end of a severed nerve, the conduit further comprises a PCL (MW:70KDa) with concentration of 10-15% and PLGA (MW:50KDa,50:50) with concentration of 10-18%.

The present invention relates to a fibrous nerve conduit for promoting nerve regeneration, comprising a channel, the channel having diameter controllable ends, the channel is adjustable to suturing to a proximal and distal end of a severed nerve, the conduit further comprises a PCL (MW:70KDa) with concentration of 10-15% and PLGA (MW:50KDa,50:50) with concentration of 10-18%.

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.

The present disclosure relates to biocompatible injectable compositions. The provided compositions comprise or consist of silk fibroin, hyaluronic acid, horseradish peroxidase, hydrogen peroxide, and water. The injectable composition is tunable and may be adapted to have a gelation time from 3 minutes to 20 minutes, a storage modulus of 6 Pa to 4000 Pa, be injectable through a needle having a size from 32 G to 18 G, have optical transmittance from 75% to 95% for at least one wavelength from 400 nm to 700 nm, have a volume expansion from 5% to 400% relative to an original volume of the hydrogel after soaking in an aqueous solution for 12 hours, and/or have a hydrogel stability by maintaining at least 75% of the storage modulus and the optical transmittance of the hydrogel after 6 months in vivo. The present disclosure provides methods for making and using the same.

The present disclosure relates to biocompatible injectable compositions. The provided compositions comprise or consist of silk fibroin, hyaluronic acid, horseradish peroxidase, hydrogen peroxide, and water. The injectable composition is tunable and may be adapted to have a gelation time from 3 minutes to 20 minutes, a storage modulus of 6 Pa to 4000 Pa, be injectable through a needle having a size from 32 G to 18 G, have optical transmittance from 75% to 95% for at least one wavelength from 400 nm to 700 nm, have a volume expansion from 5% to 400% relative to an original volume of the hydrogel after soaking in an aqueous solution for 12 hours, and/or have a hydrogel stability by maintaining at least 75% of the storage modulus and the optical transmittance of the hydrogel after 6 months in vivo. The present disclosure provides methods for making and using the same.

The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.