The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone. A method for treating a bone, the method comprising: selecting at least one reinforcing element to be combined with an injectable matrix material so as to together form a composite implant capable of supporting the bone; positioning the at least one reinforcing element in a cavity in the bone; flowing the injectable matrix material into the cavity in the bone so that the injectable matrix material interfaces with the at least one reinforcing element; and transforming the injectable matrix material from a flowable state to a non-flowable state so as to establish a static structure for the composite implant, such that the composite implant supports the adjacent bone.

A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone. A method for treating a bone, the method comprising: selecting at least one reinforcing element to be combined with an injectable matrix material so as to together form a composite implant capable of supporting the bone; positioning the at least one reinforcing element in a cavity in the bone; flowing the injectable matrix material into the cavity in the bone so that the injectable matrix material interfaces with the at least one reinforcing element; and transforming the injectable matrix material from a flowable state to a non-flowable state so as to establish a static structure for the composite implant, such that the composite implant supports the adjacent bone.

Aspects of this disclosure relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component in a perfusion pathway. In some embodiments, materials (e.g. synthetic materials) for the scaffold are printed, molded, cast, polymerized or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.

Aspects of this disclosure relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component in a perfusion pathway. In some embodiments, materials (e.g. synthetic materials) for the scaffold are printed, molded, cast, polymerized or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.

An attachment device for connecting a medical device to biological tissue of a subject includes a biocompatible scaffold including photoactive crosslinking agent and a photoactive dye to facilitate crosslinking of the scaffold with biological tissue of a subject when light is directed onto the scaffold. A conformable cover for a medical device made from the biocompatible scaffold includes strain crystallised, filaments which change shape at a predetermined temperature to conform the cover to an outer shape of the medical device. The conformable cover can be attached to biological tissue.

An attachment device for connecting a medical device to biological tissue of a subject includes a biocompatible scaffold including photoactive crosslinking agent and a photoactive dye to facilitate crosslinking of the scaffold with biological tissue of a subject when light is directed onto the scaffold. A conformable cover for a medical device made from the biocompatible scaffold includes strain crystallised, filaments which change shape at a predetermined temperature to conform the cover to an outer shape of the medical device. The conformable cover can be attached to biological tissue.

A heart valve replacement device and methods of manufacturing same are provided. The heart valve replacement device includes a substrate and a low-profile composite covering in conformal contact with the substrate and suturelessly attached to the substrate. The low-profile composite covering includes a textile base layer and a thermoplastic polymer coating integrated with the textile base layer. The thermoplastic polymer coating or select portions thereof are substantially fluid impermeable.

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.