Described herein are biocompatible materials that include a nitric oxide (NO) donor embedded in silk fibroin nanoparticles. In one aspect, the nitric oxide donor is present in the hydrophobic core of the silk fibroin nanoparticles such that the nitric oxide donor is encapsulated. The biocompatible materials described herein serve as a biocompatible and inexpensive nitric oxide delivery platform that provide sustained release of nitric oxide. The biocompatible materials are non-toxic and can be used in biomedical applications such as wound healing, where a combination of therapeutic and antibacterial properties of silk and nitric oxide are desired. Additionally, described herein are methods of making the biocompatible materials.

Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.

Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Disclosed is a medical device for use in surgery including at least one structured substrate including a plurality of structures, at least a portion of the plurality of structures being a plurality of ridges having each a length that is at least 5 times greater than their width. The ridges have at least two different cross-sections and have swellable properties, for example in the presence of water. The medical device includes at least a second substrate, including a second plurality of structures, the first and second plurality of structures being arranged to interlock when the first substrate is pressed against the second substrate in presence of water.

Disclosed is a medical device for use in surgery including at least one structured substrate including a plurality of structures, at least a portion of the plurality of structures being a plurality of ridges having each a length that is at least 5 times greater than their width. The ridges have at least two different cross-sections and have swellable properties, for example in the presence of water. The medical device includes at least a second substrate, including a second plurality of structures, the first and second plurality of structures being arranged to interlock when the first substrate is pressed against the second substrate in presence of water.

Hydrogels and hydrogel prepolymer compositions are described which include micronized eggshell particles. The hydrogels have outstanding tunability in physical, chemical, and biological properties, and have favorable properties for biomedical applications. They enable tissue formation and regeneration and are suitable for applications involving mineralized tissues such as bone, cartilage, tooth, and tendon, as well as non-mineralized tissues.

Hydrogels and hydrogel prepolymer compositions are described which include micronized eggshell particles. The hydrogels have outstanding tunability in physical, chemical, and biological properties, and have favorable properties for biomedical applications. They enable tissue formation and regeneration and are suitable for applications involving mineralized tissues such as bone, cartilage, tooth, and tendon, as well as non-mineralized tissues.