A scaffold may comprise a first polymeric electrospun fiber comprising a first material having a first degradation rate, and a second polymeric electrospun fiber comprising a second material having a second degradation rate different from the first degradation rate. The first degradation rate may substantially correspond to a cell infiltration rate, and the second degradation rate may be slower than the first degradation rate. Such a scaffold may be manufactured by electrospinning a first polymer fiber having a first degradation rate by ejecting a first polymer solution from a first polymer injection system onto a mandrel, and electrospinning a second polymer fiber having a second degradation rate different from the first degradation rate by ejecting a second polymer solution from a second polymer injection system onto a mandrel. Wound healing may be improved by applying such a scaffold to a portion of a wound.

The present invention relates to a macroscopically alignable, injectable, soft hydrogel composition which is able to form an anisotropic structure in vivo, after injection, to generate healthy functioning tissue and regenerate injured or diseased soft tissue.

The present invention relates to a macroscopically alignable, injectable, soft hydrogel composition which is able to form an anisotropic structure in vivo, after injection, to generate healthy functioning tissue and regenerate injured or diseased soft tissue.

An in situ cell bioreactor and delivery system is provided. The system is composed of toroidal-spiral particles, which encapsulate cells therein and can further provide one or more active agents. Methods for using the system in cell-based therapies are also provided.

An in situ cell bioreactor and delivery system is provided. The system is composed of toroidal-spiral particles, which encapsulate cells therein and can further provide one or more active agents. Methods for using the system in cell-based therapies are also provided.

An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including at least one growth factor, a first layer including at least one of one or more interleukins and capsaicin, and a second layer including an antigen operatively arranged to activate an innate immune system.

An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including at least one growth factor, a first layer including at least one of one or more interleukins and capsaicin, and a second layer including an antigen operatively arranged to activate an innate immune system.

Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.

Load Plan Generator (LPG) is a BIAPPS utility for generating ODI load plans based on desired subset of fact tables for loading BIAPPS Data Warehouse. The tool simplifies the configurations process by minimizing the manual steps and configurations and provides a guided list of configurations steps and checklists. The load plan components can include different sets of load plans that will be stitched together by the load plan generator to create one load plan for loading chosen fact groups in the warehouse sourcing from different transaction systems.

Load Plan Generator (LPG) is a BIAPPS utility for generating ODI load plans based on desired subset of fact tables for loading BIAPPS Data Warehouse. The tool simplifies the configurations process by minimizing the manual steps and configurations and provides a guided list of configurations steps and checklists. The load plan components can include different sets of load plans that will be stitched together by the load plan generator to create one load plan for loading chosen fact groups in the warehouse sourcing from different transaction systems.