A non-biodegradable plug-shaped implant (1) for the replacement and regeneration of biological tissue is described. The implant comprises a base section (2) configured for anchoring in bone tissue, and a top section (4) configured for growing cartilage tissue onto and into. The top section comprises a thermoplastic elastomeric material, which is porous. The thermoplastic elastomeric material comprises a linear block copolymer comprising urethane and urea groups, and may be substantially free of an added peptide compound having cartilage regenerative properties. The base section material further comprises one of a biocompatible metal, ceramic, mineral, such as phosphate mineral, and polymer, optionally a hydrogel polymer, and combinations thereof, wherein the thermoplastic elastomeric material further comprises carbonate groups.

The present invention relates to a crosslinked carboxyalkyl chitosan forming a matrix, compositions comprising same, a method for manufacturing same, and the different applications thereof, in particular in the field of therapy, rheumatology, ophthalmology, aesthetic medicine, plastic surgery, internal surgery, dermatology, gynecology or cosmetics. The invention relates in particular to a matrix comprising at least one carboxyalkyl chitosan having glucosamine units, N-acetylglucosamine units and glucosamine units substituted with a carboxyalkyl group, the carboxyalkyl chitosan having a degree of acetylation ranging from 40% to 80%, expressed as the number of moles of N-acetyl groups relative to the number of moles of total glucosamine units, the carboxyalkyl chitosan being crosslinked by covalent bonds between the chains of carboxyalkyl chitosan.

The present invention relates to a crosslinked carboxyalkyl chitosan forming a matrix, compositions comprising same, a method for manufacturing same, and the different applications thereof, in particular in the field of therapy, rheumatology, ophthalmology, aesthetic medicine, plastic surgery, internal surgery, dermatology, gynecology or cosmetics. The invention relates in particular to a matrix comprising at least one carboxyalkyl chitosan having glucosamine units, N-acetylglucosamine units and glucosamine units substituted with a carboxyalkyl group, the carboxyalkyl chitosan having a degree of acetylation ranging from 40% to 80%, expressed as the number of moles of N-acetyl groups relative to the number of moles of total glucosamine units, the carboxyalkyl chitosan being crosslinked by covalent bonds between the chains of carboxyalkyl chitosan.

An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.

An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.

An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.

The present invention relates to a glycosaminoglycan impregnated biopolymer-based scaffold implant for repairing and regeneration of damaged and diseased human menisci. The biopolymer can be any suitable natural or genetically engineered biopolymers. This scaffold implant has several advantages over prior art implants including higher biomechanical strength and lower surface friction. A method of making the scaffold implant is also disclosed.

The present invention relates to a glycosaminoglycan impregnated biopolymer-based scaffold implant for repairing and regeneration of damaged and diseased human menisci. The biopolymer can be any suitable natural or genetically engineered biopolymers. This scaffold implant has several advantages over prior art implants including higher biomechanical strength and lower surface friction. A method of making the scaffold implant is also disclosed.

Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.