The present disclosure provides a method for preparing inorganic nanoparticle-gelatin core-shell composite nanoparticles, comprising: dissolving gelatin in a aqueous solution (in which inorganic nanoparticles are dispersed in) to obtain the gelatin-contained aqueous solution, dropwise adding a polar organic solvent to obtain a suspension of inorganic nanoparticle-gelatin core-shell composite particles of nanometer size or submicrometer size, then adding a cross-linking agent thereto to cross-link the gelatin components of the composite particles, followed by washing step to finally obtain inorganic nanoparticle-gelatin core-shell composite micro/nano-particles with inorganic nanoparticles as the core and gelatin as the shell. The present invention firstly provides a process for preparing the core-shell composite nano-scaled particles with inorganic nanoparticles as the core and gelatin as the shell by using a co-precipitation method which is simple and convenient, and beneficial for applying to industrial mass production.

The present disclosure provides a method for preparing inorganic nanoparticle-gelatin core-shell composite nanoparticles, comprising: dissolving gelatin in a aqueous solution (in which inorganic nanoparticles are dispersed in) to obtain the gelatin-contained aqueous solution, dropwise adding a polar organic solvent to obtain a suspension of inorganic nanoparticle-gelatin core-shell composite particles of nanometer size or submicrometer size, then adding a cross-linking agent thereto to cross-link the gelatin components of the composite particles, followed by washing step to finally obtain inorganic nanoparticle-gelatin core-shell composite micro/nano-particles with inorganic nanoparticles as the core and gelatin as the shell. The present invention firstly provides a process for preparing the core-shell composite nano-scaled particles with inorganic nanoparticles as the core and gelatin as the shell by using a co-precipitation method which is simple and convenient, and beneficial for applying to industrial mass production.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.

The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.

Aspects of the invention relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component is a perfusion pathway. In some embodiments, materials (e.g., synthetic materials) for the scaffold are printed, molded, cast, polymerized, or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.

Aspects of the invention relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component is a perfusion pathway. In some embodiments, materials (e.g., synthetic materials) for the scaffold are printed, molded, cast, polymerized, or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.

Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.