This invention discloses a method for stabilizing bioactivity of a growth factor, including mixing collagen with a growth factor and freeze drying the mixture to remove water. After this treatment, the bioactivity of the growth factor at room temperature remains stable for at least 7 days.

This invention discloses a method for stabilizing bioactivity of a growth factor, including mixing collagen with a growth factor and freeze drying the mixture to remove water. After this treatment, the bioactivity of the growth factor at room temperature remains stable for at least 7 days.

A biological scaffold in the present invention comprises a main body, a biological material layer, and an optional tissue adhesive layer. The main body at least has a non-constituted collagen matrix. The biological material layer is coated at least on a surface of the main body, and the tissue adhesive layer is disposed at least on another surface of the main body. When the biological scaffold is adhered to a tissue through the tissue adhesive layer, a plurality of cells move from the tissue to either the adhesive layer or the biological material layer for tissue repairing or regeneration.

A biological scaffold in the present invention comprises a main body, a biological material layer, and an optional tissue adhesive layer. The main body at least has a non-constituted collagen matrix. The biological material layer is coated at least on a surface of the main body, and the tissue adhesive layer is disposed at least on another surface of the main body. When the biological scaffold is adhered to a tissue through the tissue adhesive layer, a plurality of cells move from the tissue to either the adhesive layer or the biological material layer for tissue repairing or regeneration.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Biodegradable nanofiber conical conduits for nerve repair and methods of using same are disclosed. The biodegradable nanofiber conical conduits for nerve repair and methods provide a saturable conduit having a conical shape/geometry including a larger proximal aperture and smaller distal aperture to mechanically guide the regenerating axons across the mismatched repair and thereby prevent axonal escape and neuroma formation. The biodegradable nanofiber conical conduits for nerve repair may include, but are not limited to, a conical conduit that tapers substantially linearly; a conical conduit including a conical concave shape, a conical conduit including a conical convex shape, a conical conduit including proximal and/or distal extensions, a conical conduit including an arrangement of lateral or radial ridges for crimping action, and a conical conduit filled with hydrogel for inhibiting excessive axonal growth.

Biodegradable nanofiber conical conduits for nerve repair and methods of using same are disclosed. The biodegradable nanofiber conical conduits for nerve repair and methods provide a saturable conduit having a conical shape/geometry including a larger proximal aperture and smaller distal aperture to mechanically guide the regenerating axons across the mismatched repair and thereby prevent axonal escape and neuroma formation. The biodegradable nanofiber conical conduits for nerve repair may include, but are not limited to, a conical conduit that tapers substantially linearly; a conical conduit including a conical concave shape, a conical conduit including a conical convex shape, a conical conduit including proximal and/or distal extensions, a conical conduit including an arrangement of lateral or radial ridges for crimping action, and a conical conduit filled with hydrogel for inhibiting excessive axonal growth.

An artificial blood vessel that gives a sensation of needle insertion upon puncturing and a needle thread passability resembling those of blood vessels of animals including humans, and that has high liquid leakage preventability includes two or more layers which contain a component (A) hydrogenated block copolymer and a component (B) oil, at least one of the layers further containing a component (C) lubricant. It is preferable that the artificial blood vessel has a first peak load value of 0.01 N or more and 1.2 N or less upon needle penetration by puncturing at a speed of 1000 mm/min. under the condition of 23° C.±1° C. using a universal testing machine.

An artificial blood vessel that gives a sensation of needle insertion upon puncturing and a needle thread passability resembling those of blood vessels of animals including humans, and that has high liquid leakage preventability includes two or more layers which contain a component (A) hydrogenated block copolymer and a component (B) oil, at least one of the layers further containing a component (C) lubricant. It is preferable that the artificial blood vessel has a first peak load value of 0.01 N or more and 1.2 N or less upon needle penetration by puncturing at a speed of 1000 mm/min. under the condition of 23° C.±1° C. using a universal testing machine.