A material comprising an ionically conducting polymer (ICP) positioned between and in direct contact with two electronically conducting polymers (ECP).

A medical textile product includes a textile substrate having opposed first and second surfaces with the textile substrate including a textile construction of one or more yarns. The second surface includes a coating of a substantially water-insoluble, non-porous elastomeric sealant. The one or more yarns at the first surface are pre-treated with a removable composition, such that the water-insoluble elastomeric sealant encapsulates a portion of fibers of the one or more yarns at the second surface of the textile substrate. The textile substrate is substantially impermeable to fluid. The first surface is substantially free of the substantially water-insoluble elastomeric sealant. The textile substrate may be a non-tubular substrate, such as a planar sheet, a shaped sheet, and a tape, or a tubular substrate, such as a cylindrical conduit, a tubular conduit, a Y-shaped, a T-shaped conduit, a multi-channel conduit, and a bulbous shaped conduit.

A medical textile product includes a textile substrate having opposed first and second surfaces with the textile substrate including a textile construction of one or more yarns. The second surface includes a coating of a substantially water-insoluble, non-porous elastomeric sealant. The one or more yarns at the first surface are pre-treated with a removable composition, such that the water-insoluble elastomeric sealant encapsulates a portion of fibers of the one or more yarns at the second surface of the textile substrate. The textile substrate is substantially impermeable to fluid. The first surface is substantially free of the substantially water-insoluble elastomeric sealant. The textile substrate may be a non-tubular substrate, such as a planar sheet, a shaped sheet, and a tape, or a tubular substrate, such as a cylindrical conduit, a tubular conduit, a Y-shaped, a T-shaped conduit, a multi-channel conduit, and a bulbous shaped conduit.

An implantable textile graft includes a textile tubular wall of liquid permeable textile construction of one or more yarns having opposed inner and outer surfaces. A portion of the inner surface includes a removable coating. The outer surface includes a coating of a water-insoluble, non-porous elastomeric sealant, such as a silicone-containing polymer, a polyurethane-containing polymer, and/or a polycarbonate-containing polymer, for limiting movement of fluid through the wall. The textile tubular wall is, after curing of the sealant, impermeable to water at 120 mm Hg pressure. The removable coating prevents migrating of the outer coating onto the inner surface of the textile tubular wall and the removable coating is removed prior to implantation of the graft. The portion of the inner surface of the textile tubular wall is substantially free of the water-insoluble elastomeric sealant following removal of the removable coating.

An implantable textile graft includes a textile tubular wall of liquid permeable textile construction of one or more yarns having opposed inner and outer surfaces. A portion of the inner surface includes a removable coating. The outer surface includes a coating of a water-insoluble, non-porous elastomeric sealant, such as a silicone-containing polymer, a polyurethane-containing polymer, and/or a polycarbonate-containing polymer, for limiting movement of fluid through the wall. The textile tubular wall is, after curing of the sealant, impermeable to water at 120 mm Hg pressure. The removable coating prevents migrating of the outer coating onto the inner surface of the textile tubular wall and the removable coating is removed prior to implantation of the graft. The portion of the inner surface of the textile tubular wall is substantially free of the water-insoluble elastomeric sealant following removal of the removable coating.

A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R.sup.1HN—(CH.sub.2).sub.n—NHR.sup.2 (I) [wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH.sub.2)—(CH.sub.2).sub.4—NH.sub.2, and n represents an integer of 2 to 18]. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.

A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R.sup.1HN—(CH.sub.2).sub.n—NHR.sup.2 (I) [wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH.sub.2)—(CH.sub.2).sub.4—NH.sub.2, and n represents an integer of 2 to 18]. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.

A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R.sup.1HN—(CH.sub.2).sub.n—NHR.sup.2 (I) [wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH.sub.2)—(CH.sub.2).sub.4—NH.sub.2, and n represents an integer of 2 to 18]. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.

The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.

The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.