Subject of the invention is a medical implant comprising a fiber reinforced silicone comprising (A) a silicone matrix and (B) fibers embedded in the silicone matrix, wherein the fibers comprise a comb polymer having a base polymer and side chains, wherein the base polymer is an organic polymer and the side chains comprise polysiloxanes. The invention also relates to outer shells of breast implants and uses and methods.

Subject of the invention is a medical implant comprising a fiber reinforced silicone comprising (A) a silicone matrix and (B) fibers embedded in the silicone matrix, wherein the fibers comprise a comb polymer having a base polymer and side chains, wherein the base polymer is an organic polymer and the side chains comprise polysiloxanes. The invention also relates to outer shells of breast implants and uses and methods.

A method for preparing a scaffold, said method comprising the steps of providing a solution comprising fibre-forming molecules; subjecting the solution to a cooling medium to establish a temperature difference at an interface between the cooling medium and solution; and cooling the solution as a result of the temperature difference to induce solvent crystallisation and alignment of fibres in the scaffold.

A method for preparing a scaffold, said method comprising the steps of providing a solution comprising fibre-forming molecules; subjecting the solution to a cooling medium to establish a temperature difference at an interface between the cooling medium and solution; and cooling the solution as a result of the temperature difference to induce solvent crystallisation and alignment of fibres in the scaffold.

A method for preparing a scaffold, said method comprising the steps of providing a solution comprising fibre-forming molecules; subjecting the solution to a cooling medium to establish a temperature difference at an interface between the cooling medium and solution; and cooling the solution as a result of the temperature difference to induce solvent crystallisation and alignment of fibres in the scaffold.

Provided are an absorbable biomedical composite material and a preparation method therefor. The absorbable biomedical composite material comprises: substrate granules containing a calcium-phosphorus compound; an intermediate layer which is coated on the surface of each of the substrate granules and has a first glass transition temperature, the first glass transition temperature being not higher than normal human body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The absorbable biomedical composite material has increased mechanical strength and also improved toughness.

Provided are an absorbable biomedical composite material and a preparation method therefor. The absorbable biomedical composite material comprises: substrate granules containing a calcium-phosphorus compound; an intermediate layer which is coated on the surface of each of the substrate granules and has a first glass transition temperature, the first glass transition temperature being not higher than normal human body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The absorbable biomedical composite material has increased mechanical strength and also improved toughness.

Compositions and methods are disclosed for producing polymer scaffolds for tissue engineering and drug testing. The scaffolds comprise a high molecular weight polymer having an external surface functionalized with a low molecular weight polymer to which cell surface binding molecules are attached for enhancing cell adherence to the scaffold.

Compositions and methods are disclosed for producing polymer scaffolds for tissue engineering and drug testing. The scaffolds comprise a high molecular weight polymer having an external surface functionalized with a low molecular weight polymer to which cell surface binding molecules are attached for enhancing cell adherence to the scaffold.

The present disclosure relates to the field of biomaterials, tissue engineering and regenerative medicine. Particularly, the present disclosure relates to biomaterial composite and preparation of various scaffold formats using the composite. The disclosure provides for preparation of biomaterial composite comprising silk fibroin and melanin, preparation of scaffolds with the biomaterial composite and its applications in tissue engineering, electrotherapy applications and regenerative medicine. In some embodiments, the silk fibroin is a peptide modified silk fibroin. The biomaterial composite of the present disclosure exhibits various advantages including but not limiting to enhanced antioxidant property, superior electroactive properties, improved myogenic cell differentiation, better cell growth and regeneration, and enhanced cell adhesion property.