A method includes mixing a liquid carrier and a powder formulation including an S-nitrosothiol (RSNO) powder to form a nitric oxide generating solution; and within a predetermined time of mixing, introducing the nitric oxide generating solution into an inflatable and nitric oxide permeable balloon of a urinary catheter that is inserted in a patient.

The present invention provides materials and methods for forming an interface between an appliance and living tissue using a foamed elastomeric material which contacts the tissue or similar surfaces. The elastomeric material is in the form of a durable and washable material that when applied to living tissue or similar surfaces displaces and flows in to non-conforming areas creating an air and/or water tight seal that substantially returns to an original shape when removed from the contact surface. The appliance may also include structural elements designed to optimize comfort, compliance and seal achieved through minimizing the pressure variation along the contact surface of the therapy device.

A secondary manipulator device for positioning a distal portion of an elongated medical instrument inside a patient is disclosed. The secondary manipulator device includes a retaining member having a channel configured to receive therein an intermediate portion of the elongated medical instrument. The retaining member can include a lock comprising a seat against which the elongated medical instrument can rest and a resiliently deformable retention arm that is movable relative to the seat. The lock, when in the securing state, can retain the intermediate portion within the channel to allow translating and/or rotating of the distal portion.

The two-part drip chamber includes an upper body made of a material containing one or more of Acrylonitrile Butadiene Styrene (ABS) or Polycarbonate (PC) and a lower body made of a material containing one or more of Thermoplastic Elastomer (TPE), Thermoplastic Polyurethane (TPU) or Poly Vinyl Chloride (PVC). A distal end region of the upper body is preformed in a circular ring shape, and a proximal end region of the lower body is preformed in a circular ring shape. The preformed circular ring shape region at the distal end of the upper body and the preformed circular ring shape region at the proximal end of the lower body are securely coupled in a leak-proof manner by an adhesive material selected from one or more of Cyclohexanone or Cyclohexanone with Poly Vinyl Chloride (PVC) resins, thereby producing an ergonomic elevated grip structure.