The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.

An absorbable iron-based alloy implantable medical device, including an iron-based alloy substrate and a degradable polymer coating and a zinc-containing protector which are arranged on the surface of the iron-based alloy substrate. The zinc-containing protector is selected from zinc and/or a zinc alloy, or a mixture of zinc and/or a zinc alloy and a degradable binder. The weight percentage of the zinc and/or zinc alloy in the mixture is greater than or equal to 20% and less than 100%. The zinc-containing protector is capable of delaying the corrosion of the iron-based alloy substrate during the early stage of implantation, such that the iron-based alloy substrate essentially avoids corrosion during the early stage of implantation and the clinical mechanical property requirements for the device in the early stage of implantation can be satisfied.

The invention relates to a magnesium alloy which comprises: Zn: 0.5-2 wt %, Mn: 0.2-1 wt %, Ca: 0.1-2 wt %, wherein the magnesium alloy comprises 0.6 wt % or more Mn or 0.6 wt % or more Ca, between 0.5 wt % and 1.5 wt % Mn and Ca in sum, and wherein Mg and impurities account for the remaining content in the alloy that is missing up to 100 wt %. The invention further relates to an implant of a calcium containing magnesium alloy, which is coated with a calcium phosphate layer. The invention further relates to a method of producing a biodegradable implant.

An entirely or partially implantable medical product with a negatively charged surface for repulsing bacteria has a superficially bonded substance with a permanently negative excess charge, which substance is inert against cells of the human body and the bacteria contained therein.

A synthetic bead is for implantation within the body of an animal or human body. The bead includes a surface defining a shape having a bulk volume of the bead. The surface of the bead is coated with at least a first therapeutic agent to form an inner layer; and an outer layer includes a biodegradable polymer and a second therapeutic agent positioned above the inner layer.

The present disclosure relates to an orthopedic implant. The orthopedic implant includes an elongated member having a first end and a second end opposite the first end. The orthopedic implant also includes a porous coating secured to an exterior surface of the elongated member. The porous coating includes magnesium phosphate.

The present invention relates to a method for mineralising a biopolymer membrane, comprising the following steps: a) Introduction of an assembly (3) constituted of a biopolymer membrane (4) comprised between two cellulose sheets (A) and (B), in a vessel comprising: a first compartment (1) and a second compartment (2), each comprising an electrode, a first electrode being an anode placed in the first compartment (1) and a second electrode being a cathode placed in the second compartment (2), the walls of the first compartment (1) and the second compartment (2) brought into contact with one another each having an opening placing in communication the first and the second compartments,
the assembly (3) being arranged in said opening between the first and the second compartments in such a way as to close it, the cellulose sheet (A) being on the side of the first compartment (1) and the cellulose sheet (B) on the side of the second compartment (2), b) filling the first compartment (1) with an aqueous solution containing at least one cation chosen from: calcium ions, silver ions, zinc ions, copper ions, sodium ions, magnesium ions and aluminium ions, and the second compartment (2) with an aqueous solution containing at least one anion chosen from fluoride ions, sulphate ions, carbonate ions, silicate ions and phosphate ions; c) application of an electrical voltage between the electrodes; d) turning over the assembly (3) in such a way that the cellulose sheet (A) is on the side of the second compartment and the cellulose sheet (B) on the side of the first compartment, or exchange of the solutions and electrodes of the first and the second compartments; c) application of an electrical voltage between the electrodes, said voltage being equal to that applied at step (c) and being applied for a duration identical to that of step (c); e) removal and rinsing of the assembly (3); f) recovery and drying of the mineralised biopolymer membrane.

A medical member of the present invention includes a knitted body knitted with a linear member formed in a linear shape, at least a part of the knitted body is constituted of an alloy containing titanium, tantalum, and tin, and the alloy is constituted of 15 at % to 27 at % of tantalum and 1 at % to 8 at % of tin, where the total is 100 at %, with remainder being titanium and unavoidable impurities. The knitted body is formed in a sheet shape by plain weaving, twilled weaving, plain dutch weaving, twilled dutch weaving, or stockinette stitch. Thus, there can be provided a medical member capable of dispersing a load applied to a treating site of a soft tissue.

A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.

Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.