Methods and treatments for removing contaminants from nanotube surfaces covering a medical device are disclosed herein. These methods and treatments include commencing exposure of a nanotube surface to at least one condition that at least partially removes the contaminants including: ultraviolet light, elevated temperature, plasma, and/or combinations thereof. These methods and treatments may also include orienting the nanotube surface relative to the at least one condition in order to enhance removal of the contaminants by the at least one condition. Exposure of the nanotube surface to the at least one condition may be ceased after the contaminants are at least partially removed from the nanotube surface.

The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 m in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.

The present invention relates generally to a bio-degradable implant based on magnesium having a reduced corrosion rate and to a method for the production of such an implant. It is a method for treating a surface of a bio-degradable metallic implant comprising the following steps: providing a dispersed system comprising a colloid-dispersed apatite and adding an apatite powder to the dispersed system, subjecting an implant to the dispersed system such that a surface of the implant which is to be treated is immersed in the dispersed system wherein the implant comprises a magnesium based alloy, applying an AC voltage difference between the implant as a first electrode and a second electrode positioned in the dispersed system for generating a plasma electrolytic oxidation on the immersed surface of the implant so that the immersed surface is converted to an oxide film which is at least partially covered by apatites formed by the colloid-dispersed apatite and the apatite powder. The evolution of corrosion induced hydrogen gas evolution is decreased and osseointegration is improved.

A method for co-precipitating a therapeutic agent into a hydroxyapatite coated surface includes the steps of providing a surface and applying a hydroxyapatite seed layer on the surface. The hydroxyapatite seed layered surface is contacted with a solution including the therapeutic agent and a co-precipitated therapeutic agent, hydroxyapatite layer is formed on the coated surface to uniformly distribute the therapeutic agent in the layer. Further, an implant having sustained therapeutic agent delivery includes a base and an hydroxyapatite seed layer disposed on a surface of the base. A co-precipitated hydroxyapatite coating is disposed on the seed layer. The coating includes a therapeutic agent, wherein the therapeutic agent is provided in a solution of therapeutic agent.

The present invention provides a membrane for guided regeneration of bone and tissue comprising an organic base material and a new bone formation guide layer on one or both sides of the organic base material, the new bone formation guide layer containing a hydrophilic polymer and calcium phosphate.

An implant imaging system (200) is disclosed. The implant imaging system 200 may be provided on a joint implant made of polymer. The implant imaging system (200) includes one or more metal plates (212) including at least one bone contacting surface B. The metal plates (212) are disposed on a joint implant. Further, the bone contacting surface B metal plates (212) are coated with one or more coatings of osteoconductive material. The presence of osteoconductive material increases the rate of osteointegration of the joint implant.

The disclosure relates to a method of making a bioactive coating on a fibrous article for use in a medical implant and implants comprising non-biodegradable fibers, a coating polymer layer formed from a non-biodegradable coating polymer on at least a portion of the fibers, and a bioactive coating disposed on at least a portion of the polymer coating layer. In an embodiment, a method of forming a medical implant results in bioactive ceramic particles being partly embedded in the coating polymer layer.

Stents or scaffolds made from magnesium or magnesium alloys including additives or barrier coatings that modify the corrosion rate of the stent are disclosed. Methods of forming barrier coatings that modify the corrosion rate of the stent are disclosed.

Polarized hydroxyapatite films disposed on a substrate. The films have a residual polarization of at least 5 mC/cm2. Also provided are methods of making and using polarized hydroxyapatite. The films can be used as coatings of medical devices, such as, for example, medical implants.

The present disclosure describes a coated implant for bone repair that is biodegradable. The coated implant includes an implant body formed from a magnesium alloy, and a porous ceramic coating disposed on at least a portion of an outer surface of the implant body. The porous ceramic coating can include MgO, Mg(OH).sub.2, Mg.sub.3(PO.sub.4).sub.2, and oxides of alloying elements of magnesium.