A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60 C. to about 100 C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made according to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices.

Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

An osteosynthesis system includes at least one bone plate (2), which has at least one receiving opening (8), and a bone anchor (3), which has an anchor head, the anchor head being designed to be fixed in the receiving opening by forming a form-fitting and/or frictional connection with the bone plate (2). The bone plate (2), at least in a portion including the receiving opening, and the bone anchor (3), at least in a portion including the anchor head, are each made of a magnesium alloy, the magnesium alloy of the bone anchor (3) having a different hardness to the magnesium alloy of the bone plate (2).

The present disclosure relates to medical implant components comprising a biocompatible-bioactive composite material layer (BACL), methods of making the medical implant components and applications of the medical implant components.

Embodiments of the present disclosure provide a drainage apparatuses with scar gradient control capabilities for degradable glaucoma and methods of making the same cross-reference to related applications, comprising a long-strip-shaped drainage sheet with a uniform overall cross-sectional size, wherein the drainage sheet is made of a biodegradable material, an outer surface of the drainage sheet is provided with a drainage gap that penetrates through opposite sides of the drainage sheet, an outer surface of the drainage sheet is coated with a biodegradable surface coating, and the surface coating carries an anti-scarring drug, wherein the anti-scarring drug is configured to be gradually released as the surface coating degrades, and a distribution concentration of the anti-scarring drug within the surface coating varies in a non-monotonic manner.

The invention relates to a biodegradable implant comprising a surface coated magnesium alloy or zinc alloy product, whereby the coating layer comprises oxides and/or phosphates of from rare-earth elements, Mg, Ca, Zn, Zr, Cu, Fe, Sr, Li, Mn or Ag wherein the coating is preferably generated by plasma electrolytically oxidation (PEO). The invention further comprises a method for preparing the coated magnesium or zinc alloy product of the implant.

A stent for insertion into a vessel of a patient includes an inner tube comprising a positive Poisson's ratio (PPR) material and defining a lumen extending along a longitudinal axis of the stent; and an outer tube comprising a negative Poisson's ratio (NPR) foam material and disposed around an entirety of the inner tube, the outer tube extending along the longitudinal axis of the stent. The stent is configured to exhibit an auxetic behavior in response to a deformation of the stent. An outer surface of the second portion is configured to apply a pressure to an inner surface of the vessel when the stent is implanted into the vessel and the deformation is removed.