The present disclosure provides methods of forming interlayer tissue cushions (e.g., submucosal cushions) using shear-thinning hydrogels comprising an anionic polysaccharide and layered silicate and subsequent use of the cushions for removing protrusions (e.g., lesions, such as polyps or tumors) from above the cushions. Further provided are uses, methods of treatment, and kits.

A composite anti-restenosis drug for use with a coronary drug-eluting stent, and a controlled release system for the drug. The composite drug comprises arsenic trioxide and rapamycin, which may be used in combination to prevent in-stent restenosis and reduce the incidence of intravascular thrombosis. The controlled release system for the composite drug may control the release of the composite drug so as to achieve the therapeutic effect of controlling restenosis and preventing the formation of thromboses.

The present invention provides an orthopedic implant comprising a continuous reinforced composite filament in a freely predetermined fiber orientation in multiple continuous successive layers, wherein the continuous reinforced composite filament comprises a bioabsorbable polymer matrix and a continuous bioabsorbable reinforcing fiber or fiber bundle, and whereby the continuous bioabsorbable reinforcing fiber or fiber bundle of consecutive layers at least partly intermingles and/or intertwines forming a three dimensionally interlocked continuous fiber structure.

Provided is a porous body for capturing cancer cells, including a biocompatible inorganic material, the porous body for capturing cancer cells having biocompatibility and also having stability in a living body. The porous body for capturing cancer cells can be used for application related to cancer such as a treatment, a treatment assistance, a test, or a diagnosis.

A tensile-force-enhancing tube for an implantable electrode lead or a catheter includes a tubular braid which is embedded in an elastomer material, wherein the braid comprises at least one cross thread and at least one axial thread.

The invention entails metal alloy mono and poly-filament wire reinforced carbon fiber plating system for the fixation of skeletal fractures and osteotomies. Current fracture fixation plating systems are metal alloy designs that block the field of vision of the fracture during radiographic evaluation. Carbon fiber and mono and poly-filament wire plating systems reduce the weight and thickness as compared to the current plating designs while permitting direct visualization of the fracture site during the healing process. The benefits of the plating design contribute to the satisfaction of the patient and reduce disruption to the surrounding soft tissue structures. An embodiment of the plating system entails layered sheets of carbon fiber with an infrastructural framework of metal alloy mono and poly-filament wire for added strength and durability of the plate. This system can be utilized for all types of skeletal fracture and osteotomy fixation as well as fields of mechanical, aerospace, and structural engineering where durable lightweight, high strength materials are required.

An elastomer molded body for a medical device includes an elastomer portion and a filler. The elastomer portion contains a crosslinked fluorine-based elastomer. The filler is formed from a plurality of particles each of which has aspect ratio of 5 or more and specific surface area of 3 m.sup.2/g or more and 10 m.sup.2/g or less. The aspect ratio is defined as a ratio of a dimension in a long axis direction thereof to a dimension in a short axis direction thereof. The filler has an uneven distribution in a surface layer part of the elastomer portion and is oriented in a direction along a surface of the elastomer molded body.

An elastomer molded body for a medical device includes an elastomer portion and a filler. The elastomer portion contains a crosslinked fluorine-based elastomer. The filler is formed from a plurality of particles each of which has aspect ratio of 5 or more and specific surface area of 3 m.sup.2/g or more and 10 m.sup.2/g or less. The aspect ratio is defined as a ratio of a dimension in a long axis direction thereof to a dimension in a short axis direction thereof. The filler has an uneven distribution in a surface layer part of the elastomer portion and is oriented in a direction along a surface of the elastomer molded body.

The present invention relates to a resorbable implant material made of magnesium or magnesium alloy and to a process for the production thereof. A disadvantage of the known resorbable implants is that their resorption has hitherto only been trackable using x-ray or CT examinations. The invention provides a resorbable implant material comprising homogeneously distributed fluorescent nanodiamonds in a matrix of magnesium or a magnesium alloy. Fluorescent nanodiamonds are biologically nonhazardous and provide a stable emission in the near infrared range due to nitrogen-vacancy centers (NV centres). This allows detection of the implant material in the blood plasma of the patient.

The resorbable implant material according to the invention is produced by a process wherein magnesium or a magnesium alloy is melted, nanodiamonds are added to the melt and the melt of magnesium or a magnesium alloy provided with nanodiamonds is subjected to an ultrasound treatment.

An absorbable implant material comprising homogeneously distributed Fe-doped nanodiamonds in a matrix composed of magnesium or a magnesium alloy and a method for the production thereof is provided. The absorbable implant material is produced by a method in which magnesium or a magnesium alloy is melted, Fe-doped nanodiamonds are added to the melt, and the melt composed of magnesium or a magnesium alloy that has been provided with Fe-doped nanodiamonds is subjected to an ultrasound treatment.