The present invention provides an anchor system for musculoskeletal applications, e.g., for anchoring tendons or ligaments to bone or anchoring two or more bone sections. The anchor system comprises a substantially solid pre-manufactured distal portion (i.e., anchor component) and a settable, biodegradable composite. The biodegradable composite is flowable at the time of delivery and is introduced into the fixation site before or after the anchor component. Both the anchor component and the biodegradable composite may be manufactured from citrate-based polymers.

A synthetic bead is for implantation within the body of an animal or human body. The bead includes a surface defining a shape having a bulk volume of the bead. The surface of the bead is coated with at least a first therapeutic agent to form an inner layer; and an outer layer includes a biodegradable polymer and a second therapeutic agent positioned above the inner layer.

A synthetic bead is for implantation within the body of an animal or human body. The bead includes a surface defining a shape having a bulk volume of the bead. The surface of the bead is coated with at least a first therapeutic agent to form an inner layer; and an outer layer includes a biodegradable polymer and a second therapeutic agent positioned above the inner layer.

Biodegradable and bioabsorbable anchors and anchor systems for use in musculoskeletal fixation applications comprising (1) an anchor body comprising a longitudinal axis, a proximal end, a distal end, an outer surface, and a bore extending from the proximal end and parallel to the longitudinal axis, wherein the bore defines an inner surface of the anchor body, and wherein at least a portion of the anchor body is expandable in a direction non-parallel to the longitudinal axis, and (2) an expansion pin comprising a longitudinal axis, a proximal end, a distal end, and a surface, and configured for insertion into the bore such that, when inserted, it expands the expandable portion of the anchor body in a direction non-parallel to the longitudinal axis. Both the disclosed anchors and anchor systems are at least in part formed from a citrate-based polymer.

Medical devices that are formed from a polymeric matrix including a first polymer and a functionalized polymer are provided. The medical devices may include a functionalized polymer such as maleic anhydride functionalized polymer. The burst strength and/or the hoop strength of the medical devices including the functionalized polymer may be greater than the burst strength and/or the hoop strength of control medical devices. However, the durometer of the medical devices may be substantially equal to the durometer of the control medical devices. Methods of manufacturing medical devices including a functionalized polymer are also provided.

The present invention relates to the technical field of medical devices, and in particular to an orthopedic internal fixation implant medical device, including an iron matrix and a filling material including polylactic acid and an alkaline substance. The polylactic acid has a weight-average molecular weight of M.sub.w kDa, the alkaline substance includes a metal element, the mass ratio of the metal element in the alkaline substance to the polylactic acid is p, and the p and the M.sub.w satisfy a formula of 2M.sub.w{circumflex over ()}0.8p30M.sub.w{circumflex over ()}0.5. The orthopedic internal fixation implant medical device, with good mechanical properties, can control local pH values and induce bone healing.

The present invention relates to the technical field of medical devices, and in particular to an orthopedic internal fixation implant medical device, including an iron matrix and a filling material including polylactic acid and an alkaline substance. The polylactic acid has a weight-average molecular weight of M.sub.w kDa, the alkaline substance includes a metal element, the mass ratio of the metal element in the alkaline substance to the polylactic acid is p, and the p and the M.sub.w satisfy a formula of 2M.sub.w{circumflex over ()}0.8p30M.sub.w{circumflex over ()}0.5. The orthopedic internal fixation implant medical device, with good mechanical properties, can control local pH values and induce bone healing.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

Medical devices that are formed from a polymeric matrix including a first polymer and a functionalized polymer are provided. The medical devices may include a functionalized polymer such as maleic anhydride functionalized polymer. The burst strength and/or the hoop strength of the medical devices including the functionalized polymer may be greater than the burst strength and/or the hoop strength of control medical devices. However, the durometer of the medical devices may be substantially equal to the durometer of the control medical devices. Methods of manufacturing medical devices including a functionalized polymer are also provided.

The present application provides compositions configured to be provided in a flowable, liquid form but that are configured to transition to a solid or semi-solid gel based upon a change in pH. The change in pH can arise from one or more materials utilized in the composition itself or based upon encountering an environment with a significantly different pH. The compositions are particularly suited for use as a teat sealant in non-human mammals, particularly cattle.