An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.

A polypeptide monolayer with a high surface potential and super-hydrophilicity, and a preparation method and application thereof. The polypeptide is composed of polypeptide molecules with a molecular weight of (1.48±0.2)×10.sup.5 g/mol, a height of the monolayer is 13.8-14.9 nm, the exposure of primary amino groups on the surface of the monolayer is 12-14%, a Zeta potential of the polypeptide monolayer is (−1)-5 mV; a contact angle of the monolayer is 10±1°. The monolayer serving as a surface coating material of a cardiovascular stent can be applied to treatment of cardiovascular diseases; and its super-hydrophilicity can allow a layer of hydration film to be formed on the surface of the material so as to effectively prevent protein adsorption.

A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

A method is disclosed for manufacturing a fiber-reinforced implant structure. A fiber-reinforced rigid insert is provided, comprising continuous fibers impregnated with a first thermoplastic polymer. A molding cycle is performed by overmolding. The insert is placed into a mold cavity; and a second thermoplastic polymer in melted form is injection or compression molded into the mold cavity. The insert is thus at least partly covered by the second thermoplastic polymer. The second thermoplastic polymer injection or compression in the mold cavity is cooled, thereby obtaining a molded fiber-reinforced implant structure containing the at least partly covered insert. The insert is in a predefined location in the mold cavity during said injection or compression molding and during said cooling. The first thermoplastic polymer and the second thermoplastic polymer are the same or different. Also disclosed is an implant structure, and an implant comprising said implant structure.

An implantable tubular textile graft includes a water-insoluble elastomeric sealant disposed at the textile tubular wall such that the graft is impermeable to water at 120 mm Hg pressure. The inner surface of the textile tubular wall configured to promote growth of biological tissue and/or promote growth of pseudointima.

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

This invention relates to the composition of flexible resorbable polymers with rigid resorbable fillers. The invention further relates to processing of flexible resorbable polymers with rigid resorbable fillers. The invention relates also to the use of such materials for applications in fast degradation applications. The invention also relates to the composition of flexible resorbable polymers with rigid resorbable for making shape memory materials. This invention also related to the processing of such materials by extrusion, injection molding, thermoforming, solvent mixing, and additive manufacturing. The invention also relates to the use of such materials as bone filler, vascular closure and other hemostasis devices, aneurysms, and stent applications. The invention also relates to the use of such materials as drug delivery platforms.

This invention relates to the composition of flexible resorbable polymers with rigid resorbable fillers. The invention further relates to processing of flexible resorbable polymers with rigid resorbable fillers. The invention relates also to the use of such materials for applications in fast degradation applications. The invention also relates to the composition of flexible resorbable polymers with rigid resorbable for making shape memory materials. This invention also related to the processing of such materials by extrusion, injection molding, thermoforming, solvent mixing, and additive manufacturing. The invention also relates to the use of such materials as bone filler, vascular closure and other hemostasis devices, aneurysms, and stent applications. The invention also relates to the use of such materials as drug delivery platforms.

The present invention is directed to cancer cell traps and methods of using cancer cell traps to treat and detect metastatic cancer in subjects. The cancer cell traps are administered to subjects and induce the migration and accumulation of metastatic cancer cells in the cancer cell traps.