A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

Provided herein are compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and compositions.

Described herein are nitric oxide releasing materials, methods of making nitric oxide releasing materials, and devices including nitric oxide releasing materials. The nitric oxide releasing material includes a polymer matrix having a plurality of polysiloxanes and nitric oxide-donating crosslinking moieties that covalently crosslink the polysiloxanes. Blood clotting or adhesion of a bio-material to a surface, as well as biofilm formation can be prevented using the methods and materials described.

The present invention provides compounds that inhibit Factor XIa or kallikrein and pharmaceutically acceptable salts thereof and compositions thereof. The present invention also provides methods of making these compounds or pharmaceutically acceptable salts thereof and compositions and methods of use thereof.

A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

The present disclosure relates to a coating with anti-adhesive properties (in order to repel or prevent bacterial or platelet adhesion) based on a naturally produced polymer. This polymer that has been extensively characterized and is produced by a marine bacteriumCyanothece sp. CCY 0110, at optimized production conditions to obtain increased amounts of polymer. Importantly, this strain is among the highly efficient polymer producers, secreting the polymer directly to the media, allowing the easy recovery of polymer with few purification steps, being a cost-effective product. The coating can be applied to medical devices or medical implants to prevent biofilm mediated infections thereof.

A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

A tubular woven fabric is useful as a transport hose for a fluid or a powder, as a protective hose for linear bodies such as wires, cables and conduits, as a tubular filter, or as a base material of a vascular prosthesis. The tubular woven fabric includes warp yarns and weft yarns interwoven with each other, the tubular woven fabric having an outer diameter with a variation of within 10% along the warp direction and satisfying the formula:

(L2L1)/L10.1.

Methods, devices, and kits, related to embodiments for uniformly coating at least one inner surface of a capillary with at least one anticoagulant compound.