A video image processing method includes determining a current image block and, in response to a size of the current image block meeting a preset condition, determining a temporal candidate motion vector of the current image block according to at least one of a temporal motion vector prediction (TMVP) operation or an advanced/alternative temporal motion vector prediction (ATMVP) operation.

Systems and methods are disclosed for image signal processing. For example, systems may include an image sensor and a processing apparatus. The image sensor captures image data using a plurality of selectable exposure times. The processing apparatus receives a first image from the image sensor captured with a first exposure time and receives a second image from the image sensor captured with a second exposure time that is less than the first exposure time. A high dynamic range image is determined based on the first image and the second image, wherein an image portion of the high dynamic range image is based on a corresponding image portion of the second image when a pixel of a corresponding image portion of the first image is saturated. An output image that is based on the high dynamic range image is stored, displayed, or transmitted.

Systems and methods are disclosed for image signal processing. For example, systems may include an image sensor and a processing apparatus. The image sensor captures image data using a plurality of selectable exposure times. The processing apparatus receives a first image from the image sensor captured with a first exposure time and receives a second image from the image sensor captured with a second exposure time that is less than the first exposure time. A high dynamic range image is determined based on the first image and the second image, wherein an image portion of the high dynamic range image is based on a corresponding image portion of the second image when a pixel of a corresponding image portion of the first image is saturated. An output image that is based on the high dynamic range image is stored, displayed, or transmitted.

Methods, systems, and devices for quantization parameter derivation in palette mode coding and decoding are described. An example method for video processing includes determining, for a conversion between a current block of a video and a bitstream representation of the video, that the current block is coded using a palette mode and an escape symbol value is signaled in the bitstream representation, and performing, based on the determining, the conversion, wherein a clipped quantization parameter for the current block is used in the conversion, and wherein the clipped quantization parameter used for a chroma component of the video is derived based on a quantization parameter subsequent to a mapping operation of a quantization process or a dequantization process.

A method for decoding a video according to the present invention may comprise: deriving a plurality of reference sample lines for a current block, selecting at least one among the plurality of reference sample lines, determining whether to apply an intra filter to a reference sample included in the selected reference sample line, selectively applying the intra filter to the reference sample according to the determination, and performing intra prediction for the current block using the reference sample.

A method for decoding a video according to the present invention may comprise: deriving a plurality of reference sample lines for a current block, selecting at least one among the plurality of reference sample lines, determining whether to apply an intra filter to a reference sample included in the selected reference sample line, selectively applying the intra filter to the reference sample according to the determination, and performing intra prediction for the current block using the reference sample.

A video image processing method includes determining a current image block; in response to a size of the current image block not meeting a first preset condition, skipping an advanced/alternative temporal motion vector prediction (ATMVP) operation so that a temporal candidate motion vector of the current image block is not determined according to the ATMVP operation; and encoding the current image block. The ATMVP operation includes determining a relevant block of the current image block in a temporal neighboring image; dividing the current image block into a plurality of sub-blocks; for each of the sub-blocks, determining a corresponding relevant sub-block in the relevant block; and determining temporal candidate motion vectors of the sub-blocks of the current image block according to motion vectors of the relevant sub-blocks corresponding to the sub-blocks.

A method for coding image information includes generating prediction information by predicting information on a current coding unit, and determining whether the information on the current coding unit is the same as the prediction information. When the information on the current coding unit is the same as the prediction information, a flag indicating that the information on the current coding unit is the same as the prediction information is coded and transmitted. When the information on the current coding unit is not the same as the prediction information, a flag indicating that the information on the current coding unit is not the same as the prediction information and the information on the current coding unit are coded and transmitted. At the generating of the prediction information, the prediction information is generated by using the information on the coding unit neighboring to the current coding unit

A method for coding image information includes generating prediction information by predicting information on a current coding unit, and determining whether the information on the current coding unit is the same as the prediction information. When the information on the current coding unit is the same as the prediction information, a flag indicating that the information on the current coding unit is the same as the prediction information is coded and transmitted. When the information on the current coding unit is not the same as the prediction information, a flag indicating that the information on the current coding unit is not the same as the prediction information and the information on the current coding unit are coded and transmitted. At the generating of the prediction information, the prediction information is generated by using the information on the coding unit neighboring to the current coding unit

CH1 domain variants engineered for preferential binding to either a kappa CL domain or a lambda CL domain, as well as polypeptides, e.g., antibody heavy chains or antibodies, comprising such engineered CH1 domain variants, and pharmaceutical compositions comprising such CH1 domain variants and/or such polypeptides, and methods for making and using such CH1 domain variants are provided. The CH1 domain variants minimize heavy chain-light chain mispairing and promote cognate heavy chain-light chain pairing, thereby improving the generation of multispecific, e.g., bispecific, antibodies. Also provided are methods of making CH1 domain variant libraries and methods of identifying one or more CH1 domain variants.