Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.

The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an antimicrobial agent, an organic hydroxy acid, lubricious biomedical polymer and solvent. The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant surfaces, and methods for their preparation. The present invention may be advantageously applied to medical articles as well as articles used in non-medical contexts, such as child care or food preparation.

A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.

A method for producing a collagen-containing sheet material, wherein a collagen-containing suspension is dried in such a manner that the collagen settles during drying and forms a transparent skin.

The present invention relates to a multilayer composite material for the treatment of wounds and lesions and to a dressing comprising said multilayer material.

A method of treating, reducing or preventing bacterial infection in a wound, the method comprising: applying a film on the wound, the film including a biodegradable polymer with bacteriophages dispersed therein, wherein the polymer is a poly (ester amide urea).

Medical devices with a hydrogel layer covalently attached to a portion of the outer surface of the medical device are provided along with methods for applying the coating. The hydrogel layer can include a first polymer species comprising polyethylene glycol (PEG) and a second polymer species. Examples of the second polymer species include PEG and polyacrylamide (PAM). The first and second species can be at least partially cross-linked. Methods for forming the hydrogel coatings on the medical devices are provided including nucleophilic conjugate reactions, such as Click reactions.

Provided is an antimicrobial dressing, which includes: a first cover member having a plurality of pores formed therein and contacting a wound; an antimicrobial membrane that is made by accumulating nanofibers containing a water-soluble polymer that is dissolved in an exudate secreted from the wound, a water-insoluble polymer, and an antimicrobial substance released due to dissolution of the water-soluble polymer, the antimicrobial membrane being laminated on the first cover member and having a plurality of pores formed therein; and a second cover member laminated on the antimicrobial membrane and having a plurality of pores formed therein and exposed to an external air.

A method for preparing a three-dimensional chitosan/silver composite scaffold includes mixing an acidic aqueous chitosan solution including protonated chitosan and a deposition accelerating agent being a soluble silver salt, spacedly disposing a cathode and an anode in the resultant suspension, and applying an electric field to the cathode and the anode so that the suspension undergoes electrodeposition. The suspension has a protonated chitosan concentration ranging from 0.7 to 2.8 w/v %, and a molarity of silver ions ranging from 4 to 60 mM. The composite scaffold prepared has columnar through-holes extending in a same extension direction and each having opposite first and second openings with the latter not less in width.

The present invention discloses a coating for a medical implant, wherein at least a part of said coating contains an osseointegration agent and the same and/or a different part of the coating contains an antimicrobial metal agent.