Inserts can be formed with elution characteristics to cause the inserts to elute an antimicrobial agent when subject to a fluid within a medical device. An insert can be formed with a desired geometry to allow the insert to be compression fit within a medical device to prevent the insert from moving or becoming dislodged once inserted into the medical device. The material may also be hygroscopic so that the insert swells when subject to a fluid thereby enhancing the compression fit of the device within the medical device. In some cases, the material can be reinforced using an internal structure. Inserts can be formed in many ways including by casting, thermoforming, or extrusion. In some cases, the inserts can be formed using a peel-away sleeve or material. The peel-away sleeves can be formed of a non-sticky material which facilitates removal of the inserts once the inserts have cured.

Compositions and methods for wound care or the dressing or treatment of wounds in a subject in need thereof. The compositions include an oil-based carrier, a polar solvent comprising one or more polar antimicrobial agents, and collagen or a collagen-based material. In at least some instances, the polar solvent comprising the one or more polar antimicrobial agents and the collagen or collagen-based material are suspended in the oil-based carrier.

According to one embodiment, an absorbent article includes a moisture-impervious outer layer, an inner layer substantially co-extensive with the outer layer, and an absorbent layer interposed between the outer layer and the inner layer. The inner layer is treated with at least one antimicrobial booster. The absorbent layer is treated with at least one antimicrobial agent.

A medical dressing is disclosed, the medical dressing has an adhesive layer having a skin-facing surface to adhere the medical dressing to a dermal surface, wherein said adhesive layer comprises a first chemical compound incorporated within said adhesive layer, and wherein at least a portion of said skin-facing surface has a coating comprising a second chemical compound. Also disclosed is a method of manufacturing such a medical dressing.

The present technology relates to film forming compositions comprising antimicrobial agents, as well as to methods of inhibiting bacterial growth, controlling the rate of release of an antimicrobial agent from a film forming polymer, coating a medical device, rendering the inner lumen of a medical device biofilm resistant, and treating a human or animal.

A biocidally active polymer composition formed from an oligomeric or polymeric additive and a thermoplastic polyurethane polymer is disclosed. The biocidally active polymer may further include a non-fouling and/or non-thrombogenic polymer. The biocidally active polymer provides biocidally active properties, and may also provide non-fouling and/or non-thrombogenic properties. The composition is particularly useful in articles and materials for medical applications.

The wound dressing described herein can be used as a contact layer dressing. The wound dressing can be positioned between a wound bed and a secondary dressing. The wound dressing can include a layered construction. Each of the layers can include a bioresorbable sponge enclosed within a collagen-based film. The wound dressing can include a plurality of fluid channels that enable fluid flow from the wound bed toward the environment-face side of the wound dressing.

An adhesive transparent antimicrobial sheet or film cured from a liquid containing silicone includes dispersed particulates of polyhexamethylene biguanide hydrochloride (PHMB) present at up to about 5% by weight. The dispersed particulates of PHMB are not soluble in the liquid containing silicone, and the PHMB has a molecular weight range of from 400 to 8000. Dispersed particulates of ethylenediamine tetraacetic acid (EDTA) are present at about 0.01% to about 1% by weight. The dispersed particulates of EDTA are not soluble in the liquid containing silicone. Up to 2% v/v glycerin can be included. A backing layer is on one side of the sheet or film, The sheet or film is flexible and maintains adhesiveness such that it is repositionable on tissue and/or skin with little or no tissue or skin trauma. The sheet or film does not contain chlorhexidine.

A wound or access location dressing device can be used with a transcutaneous medical device such as a cannula, a catheter, or other transcutaneous interventional device. The dressing device is formed at least partially of a flexible hydrophillic polyurethane matrix, an antimicrobial agent contained within or coupled to the matrix, and a hemostatic agent contained within or coupled to the matrix.

Inserts can be formed with elution characteristics to cause the inserts to elute an antimicrobial agent when subject to a fluid within a medical device. An insert can be formed with a desired geometry to allow the insert to be compression fit within a medical device to prevent the insert from moving or becoming dislodged once inserted into the medical device. The material may also be hygroscopic so that the insert swells when subject to a fluid thereby enhancing the compression fit of the device within the medical device. In some cases, the material can be reinforced using an internal structure. Inserts can be formed in many ways including by casting, thermoforming, or extrusion. In some cases, the inserts can be formed using a peel-away sleeve or material. The peel-away sleeves can be formed of a non-sticky material which facilitates removal of the inserts once the inserts have cured.