The present invention refers to a composition comprising: a) a crosslinked hydrophilic polymer containing amino functional groups, and b) a swelling agent, wherein the crosslinked hydrophilic polymer a) is obtainable by reacting a hydrophilic polymer containing amino functional groups with a crosslinking agent which contains at least two epoxide functional groups. The invention also refers to a method for preparing said composition and uses thereof in medical applications.

Systems, methods, and articles for providing an antimicrobial composition to the proximal elements of a trans-dermal catheter and into the lumen of the transdermal catheter are disclosed. In an embodiment, an antimicrobial composition on surface a cap element transfers antimicrobial to the proximal end of the transdermal catheter. The system comprises an elongate member configured for insertion into a lumen of a catheter, the elongate member containing an antimicrobial.

An antimicrobial catheter includes an elongated body adapted to be inserted into a body cavity of a patient that is not vascular or the urethra. An antimicrobial surface is positioned along an exterior circumferential surface of the elongated body, wherein the antimicrobial surface is configured to inhibit pathogens. The elongated body has at least one interior lumen defined by a sidewall forming the elongated body. The exterior circumferential surface extends between a first end of the elongated body and a second end of the elongated body.

A dressing device and a method of making the dressing device is disclosed. For example, the method can include forming a polyurethane foam, adhering a moisture vapor-transmissive backing to the polyurethane foam, and cutting the polyurethane foam with the moisture vapor-transmissive backing thereon to form the dressing device. Notably, forming the polyurethane foam can include mixing together a polyurethane prepolymer and an aqueous mixture of chlorhexidine di-gluconate and polyanhydroglucuronic acid or a salt of polyanhydroglucuronic acid in a first reaction vessel until a homogenous mixture is formed; dispensing the homogenous mixture onto a liner; and allowing the homogeneous mixture to expel carbon dioxide. Upon expelling the carbon dioxide, the polyurethane foam is formed with the chlorhexidine di-gluconate and the polyanhydroglucuronic acid or the salt of polyanhydroglucuronic acid homogenously dispersed throughout the polyurethane foam.

The present invention relates to wound dressings which are particularly useful (but not necessarily exclusively) on moderate to heavily exuding wounds comprising: an absorbent pad having a first major face comprised of absorbent material and configured for wound contact, and a second major face opposed to the first major face; and a backing layer bonded to the second major face of the pad; wherein the pad and the backing layer are sized such that the backing layer extends beyond the periphery of the pad, thereby defining a margin; wherein the margin of the backing layer is provided with a first adhesive for adhering the backing layer to skin; and wherein a layer of second, low trauma adhesive is provided on, and in direct contact with, the first major face of the pad for adhering the pad to a wound, said layer of second, low trauma adhesive being configured to allow passage of exudate from the wound to the absorbent pad.

A composition for treating wounds is provided. The composition includes an antimicrobial component, an emulsifying agent, and a cidatrope component. The antimicrobial component can be selected from octenidine, poly(hexamethylene biguanide), a quaternary ammonium antimicrobial compound, and salts thereof. The cidatrope is not an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkalyl carboxylic acid, a phenolic compound, a (C1-C10)monohydric alkyl alcohol, or an ether glycol. In certain embodiments, the composition can be substantially free of water and C2-C5 lower alcohols. In certain embodiments, the composition further can comprise water. Methods of using the composition are also provided.

A medical device includes a mottled structure containing silicone and an antibacterial agent at a surface of the medical device.

Inserts can be formed with elution characteristics to cause the inserts to elute an antimicrobial agent when subject to a fluid within a medical device. An insert can be formed with a desired geometry to allow the insert to be compression fit within a medical device to prevent the insert from moving or becoming dislodged once inserted into the medical device. The material may also be hygroscopic so that the insert swells when subject to a fluid thereby enhancing the compression fit of the device within the medical device. In some cases, the material can be reinforced using an internal structure. Inserts can be formed in many ways including by casting, thermoforming, or extrusion. In some cases, the inserts can be formed using a peel-away sleeve or material. The peel-away sleeves can be formed of a non-sticky material which facilitates removal of the inserts once the inserts have cured.

Inserts can be formed with elution characteristics to cause the inserts to elute an antimicrobial agent when subject to a fluid within a medical device. An insert can be formed with a desired geometry to allow the insert to be compression fit within a medical device to prevent the insert from moving or becoming dislodged once inserted into the medical device. The material may also be hygroscopic so that the insert swells when subject to a fluid thereby enhancing the compression fit of the device within the medical device. In some cases, the material can be reinforced using an internal structure. Inserts can be formed in many ways including by casting, thermoforming, or extrusion. In some cases, the inserts can be formed using a peel-away sleeve or material. The peel-away sleeves can be formed of a non-sticky material which facilitates removal of the inserts once the inserts have cured.

The present disclosure relates to methods for producing tissue matrix products with active agents to achieve localized distribution and controlled active agent release. The method can include inserting a carrier element comprising a biodegradable material and active agent into surface features of a tissue matrix product. Also provided are tissue matrix products made using the disclosed methods.