The present invention relates to wound dressings which are particularly useful (but not necessarily exclusively) on moderate to heavily exuding wounds comprising: an absorbent pad having a first major face comprised of absorbent material and configured for wound contact, and a second major face opposed to the first major face; and a backing layer bonded to the second major face of the pad; wherein the pad and the backing layer are sized such that the backing layer extends beyond the periphery of the pad, thereby defining a margin; wherein the margin of the backing layer is provided with a first adhesive for adhering the backing layer to skin; and wherein a layer of second, low trauma adhesive is provided on, and in direct contact with, the first major face of the pad for adhering the pad to a wound, said layer of second, low trauma adhesive being configured to allow passage of exudate from the wound to the absorbent pad.

The subject invention provides materials methods for reducing infections in subjects. The materials methods utilize chlorhexidine, which has been found to be surprisingly non-toxic. The lack of toxicity facilitates the use of chlorhexidine in contexts that were not previously thought to be possible.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

The present disclosure relates to topical compositions for the treatment or prophylaxis of burns. The topical compositions comprise water, solvent, thickener, preservative and conditioning agent, and are exposed to gamma radiation. One embodiment of the topical compositions includes water, propanediol, sodium acryloyldimethyltaurate/VP crosspolymer, a combination of phenoxyethanol and caprylyl glycol and chlorphenesin, polyaminopropyl biguanide (PHMB) and a mineral complex. The present disclosure also relates to the use of the topical compositions with a dressing and the use of the topical compositions and dressings in treatment or prophylaxis of burns.

An antibacterial wound dressing, a method for preparing the antibacterial wound dressing, and a use of the antibacterial wound dressing are provided. The antibacterial wound dressing is obtained by amidating carboxymethyl cellulose with a guanidine compound. The carboxymethyl cellulose has a substitution degree of 0.1-0.6, and the guanidine compound has a grafting degree of 0.2%-10.0%.

Provided herein are adhesive compositions comprising: 1) at least one adhesive of an alcohol-functionalized acrylic adhesive, an alcohol-functionalized silicone adhesive, a carboxyl-functionalized acrylic adhesive, and a carboxyl-functionalized silicone adhesive, 2) at least one phase-separated hydrophilic material, and 3) at least one bioactive compound. At least one bioactive compound may comprise an antimicrobial agent. The adhesive compositions can quickly release an antimicrobial agent and cause the rapid onset of antimicrobial effects. Also provided are adhesive products and methods using the disclosed adhesive composition.

The present disclosure provides an antimicrobial alginate fiber, a method for manufacturing an antimicrobial alginate fiber dressing thereof, and an application thereof. When the cationic polymer polyhexamethylene guanide salt is mixed with the anionic polymer alginate, the antimicrobial activity of the guanide salt is quickly passivated. The present disclosure achieves a lower content of polyhexamethylene guanide salt in an alginate dressing with good long-term antimicrobial activities. The polyhexamethylene guanide salt has a low dissolution rate, and significantly reduces a potential risk of carcinogenicity, mutagenicity and reproductive toxicity.

Orthopedic implants having antimicrobial properties and methods of producing such orthopedic implants are provided. In various embodiments, the present disclosure pertains to orthopedic implants that comprise a metal substrate and a surface coating comprising chlorhexidine or a salt of chlorhexidine on a surface of the metal substrate. In various embodiments, the present disclosure also pertains to methods of making orthopedic implants that comprise: (a) pre-treating a metal substrate to form a pretreated metal substrate and (b) applying a coating comprising chlorhexidine or a salt of chlorhexidine on a surface of the pretreated metal substrate.

A valve including an antimicrobial agent can be used with needleless access connectors. The valve can have an insert that includes an antimicrobial coating thereon and/or the valve can have physical features, such as a series of tunnels or groves or a patterned surface, containing an antimicrobial formulation and/or the valve can be made of a material that includes an antimicrobial agent.

A needleless access connector having an access port and a sustained release antimicrobial coating only on a top surface of the access port is disclosed. The top surface of the access port can be defined by a top surface of a proximal end of a housing and a top surface of a head portion of a compressible valve disposed within an internal cavity of the housing. In certain embodiments of the present disclosure, the sustained release antimicrobial coating is on: (i) the top surface the proximal end of the housing, or (ii) the top surface of the head portion of the compressible valve, or (iii) the sustained release antimicrobial coating is only on both the top surface the proximal end of the housing and the top surface of the head portion of the compressible valve.