An intravenous fluid bag comprising: a primary chamber configured to retain a liquid; a valve in fluid communication with the primary chamber, the valve including a housing, a spike element, and a seal, with the housing surrounding the seal, which surrounds the spike element; the spike element having a first end culminating in a tip, a second end having an inner conduit, and one or more through holes between the tip and the second end in fluid communication with the inner conduit forming part of a continuous liquid passageway in fluid communication with the primary chamber; the seal having a relaxed state preventing fluid flow through the valve, and the seal having a compressed state through which the through holes of the spike element extend allowing fluid flow from a source external the intravenous fluid bag, through the through holes, through the inner conduit, and into the primary chamber.

The present invention relates to a method for grafting a surface of a medical device by using quaternized trimethylamine. A catheter onto which quaternized trimethylamine has been grafted allows for the reduction of thrombus production. Therefore, the catheter having quaternized trimethylamine grafted thereto exhibits the effect of repressing thrombus production and enhancing the function of inhibiting blood adsorption and blood cell adsorption.

The present invention relates to wound care products, devices and a method for the treatment of bacterial infections. In particular it relates to a wound care dressing comprising a foamed polyvinyl acetate with bound gram positive and gram negative bactericidal dyes and a water based enzyme additive containing effective amounts of sodium chloride with iodine, citric acid and organic plant, fungus or animal enzymes to preclude or prevent biofilm.

An antimicrobial polymer for use in an ophthalmic implant, includes at least one antimicrobial monomer; and at least one other monomer selected from an acrylic, silicone, vinyl and collagen monomer.

Various embodiments of the present invention include a cannula coated or compounded with a material to extend the wear time for a patient by reducing inflammation and therefore increasing the time that the cannula may remain inserted, thereby increasing the effectiveness of the drug delivered using the cannula. The material may include a hydrophilic material, an anti-microbial material, an anti-inflammatory material, anti-thrombogenic material, or a combination of any of these materials.

Silicone-polyether copolymers, adhesives and medical articles comprising same, and methods of making same. The silicone-polyether copolymer composition can include a backbone composition having a first (silicone) segment and a second (polyether) segment connected randomly via at least one of an oxamide linkage and a urea linkage. The method of making the silicone-polyether copolymer composition can include combining: a) a first (silicone) precursor; b) a second (polyether) precursor; and c) at least one of a diisocyanate and an oxalate compound.

An antimicrobial polymer for use in an ophthalmic implant, includes at least one antimicrobial monomer; and at least one other monomer selected from an acrylic, silicone, vinyl and collagen monomer.

An antimicrobial polymer for use in an ophthalmic implant, includes at least one antimicrobial monomer; and at least one other monomer selected from an acrylic, silicone, vinyl and collagen monomer.

The invention relates to bone repair and more specifically to a berberine/mineralized collagen-based composite membrane, a preparation method, and an application thereof. The composite membrane includes a berberine nanofiber membrane and a mineralized collagen membrane disposed on a unilateral surface of the berberine nanofiber membrane. The mineralized collagen with biomimetic mineralization capacity is combined with a Chinese materia medica monomer, berberine, the resulting bilayer composite membrane has a better effect on promoting osteogenesis In addition, a novel dosage form of berberine is constructed. An electrospinning method prepares a berberine nanofiber membrane. The berberine nanofibers are received by the mineralized collagen membrane, or after the berberine nanofiber membrane is obtained, a mineralized collagen membrane is prepared by applying on the surface of the berberine nanofiber membrane.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.