The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans.

The present invention belongs to the field of biomedicine and tissue engineering. Specifically, it relates to a biomaterial and to an in vitro method for preparing a tissue or bioartificial membrane having controlled elasticity and rigidity, and to the tissue or artificial membrane obtainable using the method. The invention further relates to the uses thereof in medicine.

Provided are a pharmaceutical composition for wound healing including a surfactant, an antioxidant, a thickener, and SP, a method of treating a wound including administering the pharmaceutical composition to a subject, and a quasi-drug composition for wound healing including a surfactant, an antioxidant, a thickener, and substance. The pharmaceutical composition of the present invention reduces a wound size, generates new blood vessels, shows dermal and epidermal regeneration effects, matures granulation tissues, and synthesizes collagen, and thus may be used for wound healing.

The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans.

Described herein are methods for the treatment of hypoxia-associated tissue damage in subjects. More particularly, the methods relate to treating hypoxia-associated tissue damage in a subject during a surgical procedure with a therapeutically effective amount of a glutamine source comprising glutamine, a dipeptide comprising glutamine, or a glutamine amino ester conjugate according to particular dosing regimens. Specifically, the methods concern a dosing scheme comprising dosing a subject during a surgical procedure with a glutamine source wherein the first dose is administered to the subject within about 30 minutes following an initial surgical incision made during the surgical procedure, one or more additional doses of the glutamine source is administered at fixed intervals of time after the first dose, and one or more doses is administered just prior to closure of all surgical incisions.

A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressings comprising the materials, methods of treatment with the materials, and methods of making the materials.

The purpose of the present invention is to provide an absorbent sheet that can sufficiently absorb exudates exuding from the area of a lesion and can exhibit a powerful deodorizing effect for illness-associated odors. The present invention relates to an absorbent sheet with deodorizing functions comprising cellulosic fibers, absorbent fibers, a thermal adhesive resin and a deodorizing agent, in a single layer thereof.

A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressings comprising the materials, methods of treatment with the materials, and methods of making the materials.

An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.

A method that includes the general steps of injecting a fluid matrix of materials which chondrocytes can use to re-grow cartridge and which encourage chondrocytes to re-grow cartilage, mechanically causing the fluid matrix to travel toward chondrocytes, such as by use of a pressure cuff, an ultrasonic transducer, or other means, and exposing the chondrocytes to photonic stimulation in the range of 165 nm to 280 nm.