The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.

A reinforced biocompatible scaffold facilitates integration of biological tissue. The reinforced scaffold comprises a porous biocompatible scaffold and an arrangement of at least one biocompatible filament embedded within and fixed to the biocompatible scaffold, and/or at least one biocompatible conduit embedded within and fixed to the biocompatible scaffold.

A preparation of nano silver/dual modified chitosan antibacterial hydrogel dressing with discoloration effect for wound infection judgement and hydrogel dressing prepared by the same provided. The preparation includes the following: carrying out quaternization water-soluble modification on high molecular weight chitosan, and carrying out catecholamination water-soluble modification to prepare dual water-soluble modified chitosan; reducing silver nitrate by using the dual water-soluble modified chitosan to prepare a nano silver/dual water-soluble modified chitosan solution; adding the dual water-soluble modified chitosan, the nano silver/dual water-soluble modified chitosan, curcumin, zwitterion, acrylamide, a cross-linking agent and an initiator into deionized water in sequence, mixing and stirring uniformly, centrifugal de-foaming and casting, to prepare a nano silver/dual modified chitosan antibacterial color-changing hydrogel dressing by one-pot in-situ radical polymerization. The nano silver/dual modified chitosan antibacterial hydrogel dressing exhibits great potential for application in fields such as intelligent indicative wound repair hydrogel dressing and the like.

Methods of treating chin retrusion in a subject by increasing a glabella-subnasale-pogonion (G-Sn-Pog) facial angle of the subject are provided, which may include injecting a first volume of a dermal filler into a pogonion, injecting a second volume of a dermal filler into a mentum, and/or injecting a third volume of the dermal filler into a left pre-jowl sulcus and/or a right pre-jowl sulcus, wherein the G-Sn-Pog facial angle of the subject is increased by at least about 1° or more. Methods of treating chin retrusion are provided that may include injecting a first volume of a dermal filler into a pogonion, injecting a second volume of a dermal filler into a mentum, and/or injecting a third volume of the dermal filler into a left pre-jowl sulcus and/or a right pre jowl sulcus, wherein the chin retrusion of the subject is decreased by at least about 2 mm.

The present invention relates to compositions based on: (a) a glycosaminoglycan or mixtures thereof; (b) one or more tocopherols, tocotrienols and mixtures thereof; and (c) a selected stabilizer. The composition is a solution, with the agents not chemically bound with each other. The component (a) can be hyaluronic acid (HA) or a salt thereof; the component (b) can be a polyether clathrate a cyclodextrin, or a combination of a fatty acid with an emulsifier; the component (c) can be α-tocopherols, β-tocopherols, γ-tocopherols, δ-tocopherols; α-tocotrienols, β-tocotrienols, γ-tocotrienols, δ-tocotrienols. Preferably component (c) is vitamin E. The agents strongly cooperate to provide enhanced and more stable viscoelastic properties, resulting in a product with higher resistance to thermal treatments like e.g. heat-sterilization, autoclaving, etc. The present compositions, optionally loaded with pharmaceutically and/or cosmetically active agents, are advantageously used in medical or cosmetic methods.

Provided herein are compositions, systems, kits, and methods for treating nervous system injuries caused by trauma or neurodegeneration or aging in a subject by administering a CSPG or SOCS3 reduction peptide (CRP and SRP respectively), or a nucleic acid sequence encoding the CRP or SRP, wherein both the CRP and SRP comprise a cell membrane penetrating domain, and a lysosome targeting domain, and the CRP further comprises a chondroitin sulfate proteoglycan (CSPG) binding domain, and the SRP further comprises a suppressor of cytokine signaling-3 (SOCS3) binding domain.

A Delivery System for delivery of an Active Component is provided. The Delivery System comprises a Delivery Matrix and an Active Component. The Delivery Matrix has one or both of (i) a Cationic Component; and (ii) a Matrix Forming Substance. The Cationic Component has one or both of: (i) a cationic polymer or cationic copolymer, and (ii) a positively charged non-polymeric compound or composition. The Active Component comprises a cationic bioactive. The Delivery Matrix has a mEq amount of positive charge which is equal to or exceeds the mEq amount of positive charge of the Active Component. The Delivery Matrix may comprise chitosan, or other biopolymers, synthetic polymers, matrix polymers and large molecules, which themselves are matrix forming, or are combined with a Matrix Forming Substance and one or more other Cationic Components to form the positively charged Delivery Matrix.

The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.

The purpose of the present invention is to inhibit and prevent the formation of adhesions, i.e., bonds between a wound and its surrounding tissues or between organs that are originally separated.

The anti-adhesion material of the present invention is characterized in that at least a part of the anti-adhesion material is made of a non-biodegradable material and a contact angle of a surface to water is less than 7 degrees or more than 90 degrees.

Compositions and methods are provided to accelerate and improve wound repair and reconstruction of connective tissue structures, including tendons, by assembly of collagen using liquid crystalline collagen. The compositions and methods can be used to treat various forms of connective tissue injury or to prevent or slow degeneration to vulnerable tendons that are generally refractory to repair.