Methods and devices including amorphous magnetic microwires are provided for biomedical energy transfer for diagnosis or therapy, to promote cellular growth, or to deliver pharmaceutical agents. Applications of the technology include in sensors, actuators, and therapeutic coatings, and for increasing the amount, directionality, or length of nerve growth. The technology also can be utilized for nerve regeneration, hyperthermic treatment of tumors, vascular theranostics, probing a nerve, stimulating a nerve, sensing a biological condition, catheterization, and micro-actuation.

The present disclosure is directed to peptide-polymer conjugates, and to their use in treating intra-articular diseases or disorders.

Described herein are the use of fluid complex coacervates that produce solid adhesives in situ to anchor medical devices such as catheters in a blood vessel. The anchored devices permit the targeted delivery of bioactive agents. The anchored devices can perform as an embolic agent by reducing or preventing blood flow in the vessel. Additionally, the embolic produced from the solid adhesive produced in situ can also include one or more bioactive agents that can be released in a controlled manner.

There is provided improved therapy methods and apparatus for treating a patient's brain and spinal cord. The apparatus further relates to a flexible surgical balloon or cap-like device comprising one or more material layers that may have an antimicrobial element. The therapy apparatus may include portals for introducing diagnostic monitoring and/or therapeutic devices, and delivery of therapeutic drug delivery systems. Certain embodiments of the invention have an output emission area positioned to irradiate a portion of the brain with an efficacious power density and wavelength of light for diagnostic and/or therapeutic purposes.

Methods and compositions are described herein that promote bone formation. Such methods and compositions include SLIT3 or SLIT2 agents that can be administered to a subject (e.g., one in need thereof). Methods are also described herein that reduce or prevent unwanted bone formation. Such methods can involve administering an inhibitor of SLIT3 or SLIT2 to a subject.

An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.

Hyaluronic acid-based hydrogels, solutions for preparing such, and methods pertaining thereunto are disclosed with properties that include self-resorption, extended release of biologically active agents, and/or decreased degradation, denaturation, and/or functional inactivation of biologically active agents.

A method comprising treating a periocular wound in a subject, comprising topically administering to the periocular wound a composition comprising at least one thermoresponsive gel.

The present disclosure provides click-crosslinked hydrogels and methods of use.

The present invention relates to a drug delivery system and uses thereof. Specifically, a system that can be used to deliver therapeutic proteins, including antibodies, to proteolytic environments is disclosed. In one form of the invention the drug delivery system is a composition which comprises a porous substrate and an antibody bound to the substrate. In one embodiment, the composition comprises nanoporous silicon and can be used to deliver antibodies for the treatment, or for improving the repair, of a wound.