Once aspect of the present invention relates to methods of embolizing a vascular site in a mammal comprising introducing into the vasculature of a mammal a composition comprising an inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, which composition may be injected through a small catheter, and which compsitions gel at or below body temperature. In certain embodiments of the methods of embolization, said composition further comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound.

An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being Salinomycin.

An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.

A novel combination comprising a β-hairpin peptidomimetic of the formula cyclo(-Thr-Trp-Ile-Dab-Orn-.sup.DDab-Dab-Trp-Dab-Dab-Ala-Ser-.sup.DPro-Pro) (I), and a compound of the glycylcycline class, especially tigecycline, that enable therapeutic control of specific bacterial infections in human or animals at doses of the individual compounds lower than either of the compounds administered alone. The combination can be used as a medicament to treat e.g. skin or soft tissue infections; eye, ear, blood stream, or intra-abdominal infections; infections related to respiratory diseases, to bone diseases, to cardiovascular diseases, to genitourinal diseases, or to gastrointestinal diseases.

The invention relates to a device for producing a spacer having a stem mold (1) which has an inner space (2), wherein the inner space (2) is accessible via a proximal opening (3) and wherein the stem mold (1) has a proximal wall (4) which peripherally delimits the proximal opening (3) of the stem mold (1), a head mold (5) which has in the interior thereof a hollow space (6), wherein the hollow space (6) has a spherical surface-shaped inner surface (7) and is accessible via a distal opening (8), wherein the head mold (5) has a distal wall (9) which peripherally delimits the distal opening (8) of the head mold (5), a metal core (10) which has a stem part (12), a head part (14) and a flange (16), wherein the flange (16) projects out from the metal core (10), is arranged between the stem part (12) and the head part (14) and has a proximal surface (18) and a distal surface (20), wherein the stem mold (1) and the stem part (12) are shaped such that the stem part (12) is arranged in the inner space (2), when the proximal wall (4) is resting against the distal surface (20), and wherein the head mold (5) and the head part (14) are shaped such that the head part (14) is arranged in the hollow space (6), when the distal wall (9) is resting against the proximal surface (18).

The invention also relates to a set with such a device and to a method for producing spacers with such a device.

This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder surgeries or medical procedures.

A method of treating or preventing endocarditis in a human patient in need of therapy is disclosed. The method comprises identifying a patient inflicted with or being at risk of contracting Staphylococcus aureus, Enterococcus faecalis, or Enterococcus faecium; and locally delivering to or in the vicinity of a heart valve a therapeutically or prophylactically effective amount of rifampicin, daptomycin, dalbavancin, vancomycin, or gentamycin, or a combination of rifampicin, daptomycin, dalbavancin, vancomycin, and gentamycin. The method comprises treatment or prevention of a bacterial biofilms on the endocardium caused by Staphylococcus aureus, Enterococcus faecalis, or Enterococcus faecium.

The present invention relates to pharmaceutical compositions and methods for the treatment of peri-implant diseases, in particular peri-implant disease characterized by the destruction of the crest of the alveolar bone supporting the implant. Specifically, the method comprising the step of applying to a peri-implant bone displaying crestal resorption a 5 pharmaceutical composition comprising biocompatible bone augmentation material coated with a matrix composition which provides local controlled and pro longed release of at least one pharmaceutically active agent at the bone loss site.

A drug delivery device having an intraluminal stent for improving coronary luminal diameter of small vessels in patients with symptomatic heart disease is disclosed. The intraluminal stent includes struts having a thickness of less than approximately 110 μm. A polymer is adhered to the intraluminal stent that includes from about 50 μg/cm.sup.2 to about 150 μg/cm.sup.2 of everolimus therein. Quantitative coronary angiography measurements indicate that the drug delivery device provides an in-stent late loss of less than about 0.20 mm and an in-stent diameter stenosis of less than about 15% at 12 months following implantation in a human.

A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.

A method for implanting a medical device for implantation in a mammal joint. The method comprising the steps of creating an opening reaching from outside of the human body into the joint, providing said artificial contacting surface to said joint, fixating the artificial contacting surface to the joint, implanting said reservoir in the human body, and lubricating the artificial contacting surface with use of a lubricating fluid contained in said reservoir.