Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation N.sup.α C8-C6 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

Disclosed are a sustained-release injection formulation containing a biodegradable polymer double microcapsule that contains a conjugate of poly-L-lactic acid (hereinafter referred to as “PLLA”) filler and hyaluronic acid (hereinafter referred to as “HA”) and is capable of controlling the release rate of PLLA, and a method of preparing the same.

The present invention relates to improved clot retrieval devices, wherein at least the part of the device intended to be in contact with a clot is coated with at least one chromatin binding agent selected from the group consisting of digoxigenin, a digoxigenin derivative, distamycin and a distamycin derivative. The present invention also relates to a method of producing said improved clot retrieval device. The present invention also relates to a method of prevention and/or treatment of stroke in a subject, comprising removing at least one clot using the clot retrieval device coated with said least one chromatin binding agent.

The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

Wound dressings comprising absorbable polyelectrolyte material and ionic crystals and methods of making the same are provided. The weight percent of ionic crystals in the polyelectrolyte materials can be adjusted for desired uses of the wound dressings.

Embodiments of the disclosure include methods and compositions related to repair of weakenings or openings in a tissue of an individual, including at least a muscular wall, for example. In specific cases, a mesh comprising phosphate crosslinked poly(vinyl alcohol) polymer (PVA-P) is utilized for such methods, including for hernia repair of any kind. In particular embodiments, one side of the mesh comprises decellularized gel matrix to provide for enhanced tissue healing.

A coated urinary catheter or urinary stent device includes a urinary catheter or stent which, in a deployed position, includes or defines a protective surface area and a protected surface area and a coating upon at least a portion of the protective surface area. The coating includes a lubricant and an antimicrobial and/or pH buffering material. The device is configured such that, upon application of negative pressure to the catheter or stent, tissue of a urinary tract of a patient conforms or collapses onto the protective surface area and is thereby prevented or inhibited from occluding one or more protected drainage holes, ports or perforations of the catheter or stent.

Compositions that are suitable for use as a disinfectant are disclosed. Methods of making and using compositions that are suitable for use as a disinfectant are also disclosed.

The present invention relates to a method of treating a bone defect site in a patient. The method includes applying to the bone defect site a bone graft composition comprising a scaffold having a desired shape. The scaffold includes a biodegradable polymer and a ceramic material. The scaffold includes interconnected pores and an average porosity range of about 50% to about 90%, wherein the porosity is substantially uniform throughout the scaffold. The scaffold is bioresorbable and exhibits advantageous mechanical properties that mimic those found in natural bone. Methods of preparing the scaffolds and using them in skeletal tissue engineering applications (e.g., as bone grafts to repair osteochondral defects and ligaments) is also described.

An improved surgical device is disclosed herein. The improved surgical device includes a delivery device and a sealed container. The sealed contained is prepositioned internal to the delivery device and includes an antimicrobial solution. The improved surgical device is configured for inserting an implant into a surgical site. In some embodiments, the sealed container is configured to be manually broken to release the antimicrobial solution prior to inserting the implant into the delivery device. In other embodiments, the sealed container is configured to be automatically broken to release the antimicrobial solution prior to inserting the implant into the delivery device.