Devices prepared from polyetherimide resins are disclosed. In one aspect, the article can be medical device configured for use in a body or relating to a medical operation.

The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.

A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.

A prosthetic valve comprising a conical shaped sheet structure and a support structure, the sheet structure having a closed distal end and a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, whereby the ribbon members form a plurality of fluid flow modulating regions that close when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure, the support structure having at least one elongated cardiovascular structure engagement member that is associated with one of the ribbon members and adapted to engage a cardiovascular structure.

Devices for reducing the risk of pregnancy complications, including preterm labor and preterm birth, are disclosed herein. Also disclosed are devices in combination with therapies and medicaments for the treatment of pregnancy complications. Also disclosed are methods of using the devices for the treatment of pregnancy complications.

Pharmaceutical compositions including a gelation agent for topical delivery of active agents are disclosed. Methods for treatment of epithelial disorders using topical application of the pharmaceutical compositions disclosed herein are also described. A kit including the pharmaceutical compositions disclosed herein is also described.

A prosthetic valve comprising a conical shaped sheet structure and a support structure, the sheet structure having a closed distal end and a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, whereby the ribbon members form a plurality of fluid flow modulating regions that close when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure, the support structure having at least one elongated cardiovascular structure engagement member that is associated with one of the ribbon members and adapted to engage a cardiovascular structure.

The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.

Polymeric articles including fibers, films, and solid surfaces may be produced with improved properties by embedding particles within the article. The particles may be any particle that imparts desired properties to the fiber, film, or solid surface. Methods of selecting the particle size based upon the desired properties of the article such as the fiber diameter, film thickness, efficacy such as antimicrobial activity of the article, and/or article compositions are also described. For example, fibers having improved antimicrobial, antiviral, and antifungal properties are described. The articles having antimicrobial, antiviral, and antifungal properties may comprise a plurality of particles comprising water insoluble copper compounds that release at least one of Cu+ ions and Cu++ ions upon contact with a fluid. The average particle size or the particle size range is selected based upon the diameter of the fiber or thickness of the film to be produced.

Prosthetic valves that include conical shaped base valve members having an annular engagement end, a closed distal end region that restricts fluid flow therethrough, and a plurality of elongated ribbon members, which transition from an open fluid flow configuration to a closed fluid flow configuration in response to expansion and contraction of the base valve member, and a support structure that is configured and adapted to exert retaining forces on the annular engagement ends of the base valve members, whereby the support structure (i) conforms to the shape of the annular engagement ends of the base valve members, (ii) securely positions the annular engagement ends of the base valve members adjacent to and, thereby, in contact with a valve annulus, whereby the annular engagement ends of the base valve members conform to the shape of the valve annulus, and (iii) the annular engagement ends of the base valve members adapt to at least one fluctuation in the configuration and/or dimension of the valve annulus, whereby the annular engagement ends of the base valve members maintain contact therewith.