A variety of fill options is provided for a cell processing system. Certain options relate to a syringe assembly that receives a product directly from a separator. Other options relate to a filling system associated with the cell processing system, the filling system comprising one or more filling stations, each with at least one container, that receive product from a product container associated with the cell processing system.

A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.

Blood from a blood source is drawn into a fluid flow circuit. A mononuclear cell product is separated from the blood, followed by at least a portion of the mononuclear cell product being conveyed into an electroporation device without disconnecting the blood source from the fluid flow circuit. The electroporation device opens pores in a membrane of at least one of the cells of the mononuclear cell product to allow DNA material (which is added to the mononuclear cell product prior to electroporation) to enter and modify the genome of the cell. At least a portion of the modified mononuclear cell product is returned to the blood source. The mononuclear cell product may be washed prior to being conveyed into the electroporation device. The modified mononuclear cell product may be washed after exiting the electroporation device.

Provided is a blood component separation device that can shorten the overall time to collect high-concentration platelet liquid for blood component donation, thereby reducing time to keep a donor for blood drawing. The blood component separation device includes a temporary storage bag (also used as a buffy coat bag) which is also used as a whole blood bag for storing whole blood drawn from the donor. A control means performs whole blood drawing from the donor in parallel with performing at least either of a circulation flow step and an acceleration step, thereby storing the collected whole blood in the temporary storage bag.

A fluid processing system includes a separation device, a mononuclear cell product processing device, a pump assembly, and a controller. The controller is programmed to actuate the pump assembly to convey blood from a blood source into the separation device, actuate the separation device to separate a mononuclear cell product from the blood, and actuate the pump assembly to convey at least a portion of the mononuclear cell product through the mononuclear cell product processing device to modify a genome of at least one of the cells of the mononuclear cell product and create a modified mononuclear cell product. The controller is programmed to selectively actuate the pump system to convey the mononuclear cell product through the mononuclear cell product processing device in either a first direction or in an opposite, second direction to modify the genome of at least one of the cells of the mononuclear cell product.

A blood collection system comprises a suction unit (11), a hose arrangement (12) connected to the suction unit, means for aspirating blood and air through the suction unit and for pumping said blood and air through the hose arrangement, a flow sensing unit (14) for continuously sensing the blood flow through the hose arrangement, an anticoagulant additive dosing system (15) for continuously dosing an anticoagulant additive into the blood flowed through the hose arrangement in response to the continuously sensed blood flow, a mixing unit (16) for mixing the blood with the anticoagulant additive dosed into the blood, and a collection vessel (17) for collecting the mixed blood and anticoagulant additive. The means for aspirating and pumping the blood and air is a pump system (13) providing a known constant volume flow of the blood and air in the hose arrangement, the flow sensing unit (14) is arranged for continuously sensing the mass flow of blood through the hose arrangement by means of continuously measuring a parameter indicative of the weight of blood in a tubing section (14a), through which the blood is transported, and the anticoagulant additive dosing system comprises a control unit (15d) connected to the flow sensing unit and arranged for automatically controlling the continuously dosing of an anticoagulant additive into the blood flowed through the hose arrangement in response to the continuously sensed mass flow of blood.

A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.

The object of the invention is to provide a blood separation device that can reduce the total time for drawing blood to obtain high-concentration platelet liquid, thereby reducing the binding time of the blood donor. The device includes a temporary storage bag (Y2) (also serves as a buffy coat bag) which is a whole blood bag for storing whole blood drawn from a blood donor. The controlling unit of the device controls the device to draw whole blood from the blood donor in parallel with at least either a circulation flow step or an acceleration step, thereby storing the drawn whole blood in the temporary storage bag (Y2).

A device comprising: (a) a housing; (b) one or more pumps located within the housing, the one or more pumps configured to create a negative pressure and move fluid; (c) one or more connectors located at least partially within in the housing; (d) internal fluid paths connecting the one or more pumps to the one or more connectors; (e) one or more reservoirs connected to the one or more connectors, the one or more reservoirs being configured to collect the fluid moved by the one or more pumps; and (f) a processor configured to: (i) calculate a total volume of fluid collected in the one or more reservoirs; and (ii) indicate that the one or more reservoirs are full; wherein the fluid moved is a fluid from a wound or incision.

A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.