This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a nuclear magnetic resonance device includes a support frame, a first magnet connected to the support frame, a second magnet connected to the support frame in a manner such that the second magnet is disposed within the magnetic field of the first magnet and a magnetic attraction exists between the first magnet and the second magnet, and a spacer disposed between the first magnet and the second magnet. The spacer is configured to maintain a space between the first magnet and the second magnet.

A dialysate mixing machine may be configured to make dialysate on demand using, among other things, a plurality of concentrates in solid tablet form. For example, a prescription may be received by the dialysate mixing machine indicating the particular chemical constituents and amounts of each chemical constituent to be included in the dialysate. Based on the prescription, the dialysate mixing machine can determine the number of tablets required for each chemical constituent (and, e.g., the required amounts of other chemical constituents that are not in tablet form). The tablets are automatically dispensed and mixed with purified water, bicarbonate, and sodium chloride in a mixing chamber to produce the dialysate according to the prescription. The dialysate mixing machine may be used with and/or coupled to a dialysis machine (e.g., a hemodialysis (HD) machine designed for home use) to provide the dialysate on demand for a dialysis treatment.

A secure artificial intelligence (AI) enabled wearable medical sensor platform is used for adaptive operation according to features and techniques described herein. Operational parameters are modified based on data inputs thereto that provide feedback to the AI systems of the wearable sensor platform. The described technology can facilitate adaptive optimizations provided by AI machine learning algorithms in a manner that can beneficially assist in the monitoring and treatment of a patient. For example, the system described herein may be used for the continuous monitoring of the physiological parameters and health of a patient's vascular access point (for example, the fistula) and may provide, among other things, early warnings of possible infection at the vascular access location.

A cartridge insertion system includes a chassis supporting a fluid circuit, the chassis having a forward end with key pins projecting from the forward end and a rear end. The system also includes a medical treatment device with a slot opening closed by doors having a major dimension and having key openings spaced apart a same distance as the key pins on the chassis, such that when the chassis is pushed toward the slot opening, the key pins enter the key openings before the forward end meets the doors. The key pins push against latches that hold the door locked shut, so that the doors will not open if a cartridge without key pins is pressed against the door. When a cartridge with key pins is used, the doors unlock and allow the cartridge to be inserted.

Constraining adaptive optimizations of a state of an operation module of a medical device includes determining if a new state has at least one operational parameter that is outside a constraint that has been provided to the medical device in a non-repudiable manner, accepting the new state if no operational parameters are outside any of the constraints, and reverting the medical device to a previous valid state if at least one operational parameter is outside at least one of the constraints. The adaptive optimizations may be provided using artificial intelligence along with relevant inputs thereto. The medical device may be a dialysis system. Constraint data may be provided to the medical device along with a one-way hash value of the constraint data using, for example, a SHA 256 hash. The one-way hash value may be digitally signed using a private key that is part of a public/private key pair.

A disposable medical flow-regulating assembly includes flow-directing units, with multiple fluid-flow lines entering each of the flow-directing units. The flow-directing units are interconnected by a fluid-flow line that extends between them. Each of the flow-directing units includes a rotational insert member that regulates which of multiple flow passages through the flow-directing unit is open and which are closed, based on the angular position of the insert member.

Dialysis machines and methods for operating dialysis machines (e.g., peritoneal dialysis machines) may include delivering dialysate to a patient and detecting a temperature of a volume of the dialysate, an air content of the dialysate volume, or another condition, or combinations thereof, wherein the detected temperature of the dialysate volume is compared to a predetermined maximum temperature, the detected air content of the dialysate volume is compared to a predetermined maximum air content and the detected other condition generates a signal. The volume of dialysate may be diverted in response to the detected temperature exceeding the predetermined maximum temperature, the air content exceeding the predetermined maximum air content, or the other condition generated signal, or combinations thereof.

A method for operating a dialysis machine to conduct a dialysis treatment on a patient (e.g., a peritoneal dialysis machine) may include transferring dialysate from a first bag, and automatically determining the dialysate from the first bag has completely transferred. After determining the dialysate has completely transferred from the first bag, switching from the first bag to a second bag of dialysate. The method may further include transferring dialysate from the second bag in response to the detection of the completed transfer of the first bag, and automatically determining the dialysate from the second bag has completely transferred. The method may further include determining if the respective first or second bag has completely transferred by comparing a dialysate bag volume transferred to the patient to a detected volume of the respective first or second bag. Systems with dialysis machines for performing such a method are disclosed as well.

A secure artificial intelligence (AI) enabled wearable medical sensor platform is used for adaptive operation according to features and techniques described herein. Operational parameters are modified based on data inputs thereto that provide feedback to the AI systems of the wearable sensor platform. The described technology can facilitate adaptive optimizations provided by AI machine learning algorithms in a manner that can beneficially assist in the monitoring and treatment of a patient. For example, the system described herein may be used for the continuous monitoring of the physiological parameters and health of a patient's vascular access point (for example, the fistula) and may provide, among other things, early warnings of possible infection at the vascular access location.

Devices, systems, and methods herein relate to predicting infection of a patient. These systems and methods may comprise illuminating a patient fluid in a fluid conduit from a plurality of illumination directions, measuring an optical characteristic of the illuminated patient fluid using one or more sensors, and predicting an infection state of the patient based at least in part on the measured optical characteristic.