A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to monitor an amount of fluid withdrawn from a heater bag line during a PD treatment. A processor in the control unit is configured to operate a first pump to draw fluid into a first pump chamber and measure a first fluid volume in the first pump chamber. The processor is further configured to operate the first pump and a second pump to transfer fluid from the first pump chamber to a second pump chamber, measure a second fluid volume in the second pump chamber, and determine a measured fluid volume for a single pump cycle based on the first fluid volume and the second fluid volume. The first fluid volume is correlated to the second fluid volume and, therefore, the multiple independent measurements increase an accuracy of the fluid volume measurement.

The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. According to one aspect, a blood pump is configured to pump blood to a dialyzer of a hemodialysis apparatus, the blood pump comprising a pneumatically actuated or controlled reciprocating diaphragm pump. In an embodiment, the diaphragm of the pump comprises a flexible membrane formed or molded to generally conform to a curved inner wall of a pumping chamber or control chamber of the pump, wherein the diaphragm is pre-formed or molded to have a control side taking a convex shape, so that any elastic tension on the diaphragm is minimized when fully extended into a control chamber of the pump. In another aspect, a system for monitoring the adequacy of blood flow in a blood line of the hemodialysis apparatus allows a controller to suspend dialysate pumping operations if the adequacy of blood flow in the blood line is sub-optimal, and to present information on a display on the quality of blood flow in the blood line.

This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a nuclear magnetic resonance device includes a support frame, a first magnet connected to the support frame, a second magnet connected to the support frame in a manner such that the second magnet is disposed within the magnetic field of the first magnet and a magnetic attraction exists between the first magnet and the second magnet, and a spacer disposed between the first magnet and the second magnet. The spacer is configured to maintain a space between the first magnet and the second magnet.

A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

The present specification describes a modular, portable hemofiltration system, for providing improved clearance levels of blood toxins, which includes at least one roller pump that is designed and operated to generate a rapidly varying pressure profile of fluid within at least a blood circuit of the hemofiltration system.

A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

Methods, device, and systems for preparing peritoneal dialysis fluid and/or administering a peritoneal dialysis treatment are disclosed. In embodiments, peritoneal dialysis fluid is prepared at a point of use automatically using a daily sterile disposable fluid circuit and one or more long-term concentrate containers that are changed only after multiple days (e.g. weekly). The daily disposable may have concentrate containers that are initially empty and are filled from the long-term concentrate containers once per day at the beginning of a treatment.

A treatment device system includes a treatment machine for generating custom peritoneal dialysis solution and including at least one fluid conveyor, the treatment machine having a controller, the controller having a first memory, configured to produce a therapeutic fluid by causing the at least one fluid conveyor to mix purified water and at least one concentrate. The system also includes a user interface and a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including internal central controller, the internal central controller having a second memory, to control preparation of the purified water. A server is communicatively coupled with the treatment machine and a control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier.

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to operate in a hybrid automated mode during a PD treatment. A processor in the control unit is configured to engage a pump during a fill phase of the PD cycle. The volume of fluid (e.g., dialysate) transferred to a patient line during the fill phase is monitored. After a dwell period, the pump is disengaged at the start of a drain phase of the PD cycle. Disengaging the pump can include: configuring valves of a disposable cassette to bypass the pump chambers of a disposable cassette; activating a bypass valve to shunt the patient line to a drain line; or moving a roller assembly of a peristaltic pump. The fluid transferred from the patient line to the drain line is monitored during the drain phase of the PD cycle.

A system for processing fluids and filling a container with a product includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a drive coupled to the spinning membrane separator, first and second syringe pumps, the first and second syringes coupled to the first and second syringe pumps respectively, and a controller. The system also includes a syringe pump for filling low-volume containers, which syringe pump may be one of the first and second syringe pumps, or may be a third syringe pump. The syringe pump for filling low-volume containers may include a filtered vacuum/pressure source and a position detector.