An example renal therapy system includes a blood pressure monitor configured to output blood pressure data concerning a patient and a renal therapy machine communicatively coupled to the blood pressure monitor. The renal therapy machine is configured to generate ultrafiltration (“UF”) removed data from a prescribed renal therapy treatment performed by the renal therapy machine on the patient, and transmit the UF removed data and the blood pressure data via a network. At least one of a UF trend or a blood pressure trend from the UF removed data or the blood pressure data is determined, enabling a further determination as to at least one of (a) whether a prescribed renal therapy treatment adjustment or a new prescribed renal therapy treatment needs to be made, (b) whether the patient is complying with the prescribed renal therapy treatment, or (c) whether a condition related to an alarm or an alert exists.

A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

A peritoneal dialysis system is provided that includes a hardware unit, a disposable unit received by the hardware unit, and a controller. The hardware unit includes a recessed area, a piston having a contact surface, a pneumatic source for supplying a negative pressure, and an actuator configured to move the contact surface of the piston into and out of at least a portion of the recessed area. The disposable unit includes an outer member fitted at least partially within the recessed area of the hardware unit and a moveable membrane positioned between the contact surface of the piston and the outer member when the disposable unit is received by the hardware unit. The controller is configured to cause the pneumatic source to apply the negative pressure to the moveable membrane so as to conform the moveable membrane to a shape of the contact surface of the piston and follow the contact surface when the piston is moved towards and away from the outer member fitted at least partially within the recessed area.

A machine is provided with a slot to releasably receive and retain a cartridge in which dialysis is effected. The machine is configured for supplying to the cartridge, at a controlled temperature and rate, sterile water for use in haemodialysis and is operable to maintain, in a sterile condition, residual water contained therein after completion of a haemodialysis treatment.

A peritoneal dialysis system includes (i) a fill container, and (ii) an energizing unit that removably accepts the fill container, the energizing unit including a sterilization source so configured and arranged relative to the fill container when accepted by the energizing unit to place fluid within the fill container in a physiologically safe condition for delivery to the peritoneal cavity of a patient.

Described here are systems, devices, and methods of renal replacement therapy. In some variations, a continuous ambulatory dialysis device may comprise a first fluid conduit configured to receive a fluid from a patient, a second fluid conduit configured to output the fluid to the patient, and an electroosmotic pump configured to pump and filter the fluid. The electroosmotic pump may be coupled between the first fluid conduit and the second fluid conduit. The electroosmotic pump may comprise a first electrode configured to adsorb urea in the fluid, a second electrode, and a porous substrate coupled therebetween.

A dialysis system includes a dialysis instrument including a blood pump, a dialysate inlet pump, a dialysate outlet pump, and at least one fluid velocity sensor, each sensor including an emitter and a receiver, a dialyzer arranged (i) to receive blood pumped by the blood pump, (ii) to receive fresh dialysate pumped by the dialysate inlet pump and (iii) such that used dialysate is pumped from the dialyzer by the dialysate outlet pump, and a disposable cassette including a to-dialyzer dialysate pathway carrying dialysate pumped by the dialysate inlet pump and a from-dialyzer dialysate pathway carrying used dialysate pumped by the dialysate outlet pump, wherein at least one of the to-dialyzer dialysate pathway or the from-dialyzer dialysate pathway includes at least one sensing area so positioned and arranged such that when the disposable cassette is mounted to the instrument, the sensing area is coupled operably with both the emitter and the receiver of the at least one fluid velocity sensor.

A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.

A system for dialysis is disclosed. An example peritoneal dialysis system includes a peritoneal dialysis machine including a pumping mechanism, and a sensor configured to measure a property of peritoneal dialysis fluid. The peritoneal dialysis system also includes a disposable cassette operable with the peritoneal dialysis machine. The disposable cassette includes a fluid source inlet for accepting fluid from a fluid source and a fluid flow path in fluid communication with the fluid source inlet. The fluid flow path includes a pump chamber operable with the pumping mechanism to pump fluid through the fluid flow path. The disposable cassette also includes a concentrate inlet for fluidly communicating concentrate to the fluid flow path, and a sensor chamber located along the fluid flow path and operable with the sensor. The sensor is configured to provide feedback to the peritoneal dialysis machine for mixing the concentrate for forming peritoneal dialysis fluid.

A dialysis system has a module with a dialyzer configured to remove one or more substances from a dialysis solution as it passes through a dialyzer. The module has a fluid line, a sorbent cartridge, and a sodium control system adapted to actively alter a sodium concentration of dialysis solution passing through the fluid line as the dialysis solution exits the sorbent cartridge. The sodium control system has a conductivity sensor that sends a signal indicating the conductivity of the dialysis solution as the dialysis solution exits the sorbent cartridge, the conductivity meter being in communication with the sodium control system, a processor configured to receive the signal from the conductivity sensor, compare the conductivity signal to a threshold value lower than a prescription value, and cause the sodium control system to stop actively altering the sodium concentration if the signal is greater than the threshold value.