In one aspect, a valve actuation system includes a drive unit including an actuator configured to engage and move multiple valves disposed within a fluid cassette to selectively open and close each valve of the multiple valves and a positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the multiple valves.

A dialysis machine operable with a disposable set having at least one container, the dialysis machine including a pump actuator operable to pump dialysis fluid to and/or from the at least one container; a weigh plate positioned to support the at least one container; a plurality of operational load cells positioned to support the weigh plate; a linear actuator positioned to apply a force to the weigh plate; a calibration load cell positioned to measure the force applied by the linear actuator; and a control unit in operable communication with the operational load cells, the linear actuator and the calibration load cell, the control unit configured to cause the linear actuator to apply the force to the weigh plate, compare resulting outputs from the operational load cells and the calibration load cell, and determine a calibration factor from the comparison for offsetting future outputs from the operational load cells.

In one aspect, a valve actuation system includes a drive unit including an actuator configured to engage and move multiple valves disposed within a fluid cassette to selectively open and close each valve of the multiple valves and a positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the multiple valves.

A dialysis system includes include a home dialysis machine and a home gateway device in communication with a cloud-based application via a connected health system. The gateway device has voice recognition capabilities. A user can provide spoken information to the gateway device, and the gateway device can cause one or more actions to be performed. The gateway device may cause a dialysis function to be performed by the dialysis machine, or data to be input into the dialysis machine. The gateway device can also communicate with one or more other systems (e.g., remote systems) via the cloud-based application. In some examples, the cloud-based application can communicate with an order management system to allow the user to order medical supplies (e.g., for use with the dialysis machine) via the gateway device. The gateway device can provide two-way conversational capability (e.g., back and forth communication) between the user and the gateway device.

A peritoneal dialysis system for detecting peritonitis is disclosed herein. In one example, an impedance measurement system includes an impedance monitor configured to sense an impedance of peritoneal dialysis (“PD”) fluid residing within a fluid line. The impedance monitor includes a first conductive lead disposed within a first port along the fluid line and a second conductive lead disposed within a second port along the fluid line. The impedance measurement system also includes a control unit electrically coupled to the impedance monitor. The control unit uses the sensed impedance from the impedance monitor to detect white blood cells to form a patient peritonitis determination. The control unit may communicate the peritonitis determination to alert a clinician.

An inductive inline dialysis fluid heater is disclosed. In an example, a dialysis fluid heater includes a cylindrical tube including an inner diameter that is between 4.00 millimeters (“mm”) and 12.7 mm. The dialysis fluid heater also includes a susceptor located within the cylindrical tube and an inductive coil extending around the cylindrical tube in a non-contacting arrangement. The dialysis fluid heater further includes power electronics in electrical communication with the inductive coil and configured to supply an electrical current to the inductive coil, causing the susceptor to heat.

A fluid purification unit is disclosed. In an example, a fluid purification unit includes a heater configured to boil a fluid. The heater includes first and second electrodes positioned and arranged to contact the fluid. The first and second electrodes are configured to receive electrical power, heat resistively due to the electrical power, and transfer the heat to the fluid to boil the fluid to form water vapor. The fluid purification unit also includes a condenser including (i) a thermally conductive flowpath configured to conductively cool the water vapor, and (ii) a cooling source configured to direct a cooling medium past the thermally conductive flowpath to convectively cool the water vapor. The conductive and convective cooling combines to condense the water vapor into purified water.

This disclosure relates to medical fluid cassettes and related systems and methods. In certain aspects, a medical fluid cassette includes a base having a first region and a second region, a first membrane overlying the first region of the base, and a second membrane overlying the second region of the base. The second membrane is configured to rebound away from the base when a force used to press the second membrane toward the base is released.

A device for monitoring and/or modifying a peritoneal dialysis treatment, including a memory which stores at least one treatment protocol; a control circuitry connected to the memory, wherein said control circuitry generates a report and/or modifies the treatment if an outcome of the treatment is not a desired outcome of the treatment protocol.

Systems and devices are provided for heating an infusible liquid. The inline heater includes a fluid flow channel defined by a conduit for flowing an infusible liquid through a first portion of the conduit having a first cross-sectional dimension to a second portion of the conduit having a smaller second cross-sectional dimension. A nozzle is disposed in the first portion of the conduit. A heating element in thermal communication with an outer surface of the second portion of the conduit conducts heat through the conduit into the infusible liquid. The nozzle is positioned to spray the infusible liquid about a circumference of an inner wall of the second portion of the conduit to provide increased heat transfer from the heating element to the infusible liquid. The inline heater may be formed as a cassette for use in a dialysis machine.