A novel highly stable sodium diacetate crystal, in which the volatilization of acetic acid can be suppressed for a long period. More specifically, a sodium diacetate crystal having a median diameter in the range of 300 to 3000 m.

Provided herein are methods for maintaining physiological levels of thiosulfate in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium thiosulfate to a subject undergoing hemodialysis.

A method for determining a treatment regimen for altering the treatment parameters when dialyzing a patient over a plurality of treatment sessions taking place on future days includes determining a diffusive total target sodium balance; and determining a transitional treatment regimen by which the diffusive total target sodium balance is achieved over the plurality of future treatment sessions. A control device or closed-loop control device is configured to control a blood treatment apparatus using the method.

A method of treating acute hypovolemia due to one or more medical conditions including sepsis with shock, hemorrhagic shock, burn injury, nephritic syndrome, and multiorgan failure by injecting an aqueous solution of hypochlorous acid to a patient in need thereof.

The present disclosure provides compositions and methods for treating cancer with nutritionally modified diets and/or dialysis treatment, such as through amino acid depletion of one or more nonessential amino acids. In some aspects, the present disclosure provides compositions and methods for treating obesity with such modified diets and/or dialysis treatment. Furthermore, in some aspects, the present disclosure provides compositions and methods for treating renal disease with such modified diets and/or dialysis treatment.

A hemodialysis device and method are provided in which a hemodialyzer is designed for blood to flow past a semipermeable membrane and for a dialysate to flow in the opposite direction on the other side of the semipermeable membrane where uremic solutes are capable of diffusing from the blood into the dialysate passing the semipermeable membrane, and further designed in which a sorbent incorporated in a dialysate path as the dialysate passes the semipermeable membrane. The sorbent binds to non-urea uremic solutes and in particular to non-urea uremic solutes that bind to plasma proteins. In addition, the sorbent binds urea and inorganic ions much less effectively than non-urea uremic solutes and in particular to non-urea uremic solutes that bind to plasma proteins.

A method for adjustment of a dialysate during dialysis for a patient is provided. A patient undergoing a dialysis treatment, e.g., a hemodialysis (HD) treatment, can experience multiple physiological changes during the treatment. These can include change in blood volume as well as change in concentration of blood electrolytes. Blood electrolytes when taken out of their desired ranges can result in one or more health risks. The disclosure provides a way of avoiding those health risks by adjusting composition of dialysate during dialysis treatment such that blood electrolytes are maintained within their desired ranges.

Provided herein are methods for maintaining physiological levels of thiosulfate in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium thiosulfate to a subject undergoing hemodialysis.

The present invention relates to a medical solution. According to the invention the ready-for-use solution comprises phosphate in a concentration of 1.0-2.8 mM, is sterile and has a pH of 6.5-7.6. The present invention further relates to a method for producing the medical solution and the use thereof.

The present invention relates to a medical solution. According to the invention the ready-for-use solution comprises phosphate in a concentration of 1.0-2.8 mM, is sterile and has a pH of 6.5-7.6. The present invention further relates to a method for producing the medical solution and the use thereof.