A bioartificial liver (BAL) based on human induced pluripotent stem cells (iPSCs)-derived hepatocyte-like cells (HLCs) and a multilayer porous bioreactor is provided. The plasma separation/retransfusion loop part includes a blood input pipe, an exhaust pipe spring clamp, a blood input peristaltic pump, a heparin pump, a plasma separation column, a first pressure monitor, and a heater. The cell reactor/plasma component exchange double-loop part includes a plasma input peristaltic pump, and a semipermeable membrane exchange column, a plasma exchange peristaltic pump, a red blood cell (RBC) pool, a membrane lung, a multilayer porous bioreactor, a second pressure monitor, and a third pressure monitor arranged in a 37° C. dedicated incubator. An outlet of the third pressure monitor and a blood cell outlet are connected to an inlet of the first pressure monitor, and then connected to the heater and a blood output pipe in sequence.

The present disclosure discloses an integrated membrane oxygenator including an oxygenator and a filter attached to the oxygenator. The oxygenator may include an upper cover, a lower cover, a shell, and an oxygenation structure. Two ends of the filter may be respectively connected with the upper cover and the lower cover. The oxygenation structure may include a mandrel, an oxygen pressure membrane, and a temperature-changing membrane arranged inside the shell. The filter may include a filter shell, a diversion structure, and a filter screen arranged inside the filter shell. An inlet of the filter shell may be connected with a blood outlet on the lower cover of the oxygenator, and blood oxygenated by the oxygenator may directly enter the filter for filtration.

This document describes stepper motor drive systems. The stepper motor drive systems can be used in many different applications including, for example, to drive a stepper motor of an occluder device in association with a heart-lung machine.

The embodiments of the present disclosure may provide a membrane oxygenator with a built-in filter, including an upper cover, a lower cover, a shell and an oxygenation structure, wherein two ends of the shell may be respectively connected to the upper cover and the lower cover, and the oxygenation structure may be disposed in the shell, including a mandrel, a filter screen, an oxygen pressure membrane, and a temperature-changing membrane in turn from a center to an outside. The blood may flow in from an upper blood inlet of the membrane oxygenator, traverse the temperature-changing membrane, oxygen pressure membrane and filter screen in turn, and then flow out from a blood outlet under the mandrel. During a process of traversing, a flow rate of the blood may gradually slow down, and the blood may fully contact the oxygen pressure membrane and the filter screen.

In a method for manufacturing an oxygenator, an intermediate spacer is disposed between a cylindrical heat exchange unit configured by winding a first hollow fiber membrane and a cylindrical gas exchange unit configured by winding a second hollow fiber membrane so that a first gap is formed between one end portions of the heat exchange unit and the gas exchange unit, and a first partition section of a first cover member is inserted into the first gap. In such an oxygenator, a first end portion of the intermediate spacer is located at a part that does not overlap the first partition section in a radial direction in the heat exchange unit and the gas exchange unit. The intermediate spacer is formed by winding an intermediate hollow fiber membrane.

A circuit for extracorporeal blood circulation comprising a feeding line(s) adapted to take blood to be treated from a patient and a return line(s) adapted to reintroduce treated blood into the patient; at least one oxygenation device connected at inlet to the feeding line and at outlet to the return line and at least one inlet port of the blood to be treated and at least one outlet port of the treated blood, at least one inlet channel and at least one outlet channel of a working gas comprising at least one of either air or oxygen to supply oxygen to the blood to be treated and/or to remove carbon dioxide therefrom; at least one feeding device of the working gas connected to the inlet channel; and an ozone dispensing device(s) connected to the inlet channel to introduce ozone into working gas entering the oxygenation device.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit, such as veno-venous extracorporeal membrane oxygenation, includes determining (i) a first arterial carbon dioxide content or surrogate and (ii) a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; establishing a second removal rate of carbon dioxide from the blood in the oxygenator in the extracorporeal blood oxygenation circuit; determining (i) a second arterial carbon dioxide content or surrogate and (ii) a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood; and calculating a cardiac output of the patient corresponding to a blood flow rate through the extracorporeal blood oxygenation circuit, the first arterial carbon dioxide content or surrogate, the first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; the second arterial carbon dioxide content or surrogate and the second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood.

A transportable extracorporeal system includes a housing, a blood flow inlet, a blood flow outlet, a plurality of hollow gas permeable fibers, a gas inlet in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with outlets of the plurality of hollow gas permeable fibers, a first moving element, a concentrated oxygen generating device, a second moving element, a hollow transport conduit having a proximal opening and a distal opening and a power source configured to provide power to the first and second moving elements. The plurality of hollow gas permeable fibers comprising a gas transfer membrane. The concentrated oxygen generating device is configured to recycle waste oxygen from the gas transfer membrane to increase throughput and remove, by an adsorption/desorption process, unwanted gasses.

The invention relates to a heat exchanger tube (1) which is a component of a heat exchanger of an oxygenator. The heat exchanger tube (1) comprises a tube body (2) consisting of thermoplastic polyurethane (PTU). The tube body (2) has a Shore hardness of greater than 60 D. This results in a heat exchanger tube optimised for use in a heat exchanger of an oxygenator.

Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.