In one exemplary embodiment, a wearable extracorporeal life support device includes a catheter fluidly connected to a pump and first and second modular extracorporeal life support components. The device may also be configured to be attached to a garment. The pump and the first and second modular extracorporeal life support components may be fluidly connected in series. The pump and the first and second modular extracorporeal life support components may also be fluidly connected in parallel. The first modular extracorporeal life support component may be a lung membrane and the second modular extracorporeal life support component may be a dialysis membrane.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit includes determining the cardiac output corresponding to a blood flow rate through an extracorporeal blood oxygenation circuit, a first arterial carbon dioxide content or surrogate, a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to a first removal rate of carbon dioxide from the blood; a second arterial carbon dioxide content or surrogate and a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to a second removal rate of carbon dioxide from the blood.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit includes measuring first oxygenated blood flow rate by a pump in the extracorporeal circuit and a corresponding arterial oxygen saturation and recirculation in the extracorporeal circuit, then changing the pump flow rate, such as decreased, to produce a corresponding change in arterial oxygen saturation (wherein such change is outside of normal operating variances or drift), which change in the arterial oxygen saturation and recirculation are measured. From the first flow rate and the second flow rate along with the corresponding measured recirculation and the arterial oxygen saturation, the CO of the patient can be calculated, without reliance upon a measure of venous oxygen saturation. The system also includes an accommodation of oxygenation by the lungs of the patient during the extracorporeal blood oxygenation.

In one exemplary embodiment, a wearable extracorporeal life support device includes a catheter fluidly connected to a pump and first and second modular extracorporeal life support components. The device may also be configured to be attached to a garment. The pump and the first and second modular extracorporeal life support components may be fluidly connected in series. The pump and the first and second modular extracorporeal life support components may also be fluidly connected in parallel. The first modular extracorporeal life support component may be a lung membrane and the second modular extracorporeal life support component may be a dialysis membrane.

Disclosed is a membrane oxygenator, comprising a housing, and a blood-oxygen exchange chamber arranged in the housing. A liquid inlet side of the housing is provided with at least two blood inlets, and a liquid outlet side of the housing is provided with at least two blood outlets. The liquid inlet side and the liquid outlet side are respectively located at either side of the housing. Projections of blood inlets at the liquid outlet side do not coincide with blood outlets. By designing the shape of the blood-oxygen exchange chamber, blood inlets and blood outlets, and a blood inlet porous baffle of the membrane oxygenator in a mode fits to the shape design of the blood-oxygen exchange chamber and blood inlets, the effects of evenly distributing the blood flow to enable full blood-gas exchange, relieving the blood stasis and the like are achieved, and thus reduce the clinical thrombosis risk.

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

An oxygenator (10) has a hollow fiber module (19), a cylindrical outer tube (22) that accommodates the hollow fiber module (19), and a sealing structure (82a, 82b) that seals a gap between an outer peripheral portion of the hollow fiber module (19) and an inner peripheral portion of the outer tube (22). The sealing structure (82a, 82b) includes an anchor structure (84a, 84b) that is formed on the outer tube (22) on an inner peripheral side near the end defining a groove recessed in an axial direction of the outer tube (22), a cutout portion (88) formed by cutting out the anchor structure (84a, 84b) on the inner peripheral side, and a sealing material (86a, 86b) with which the anchor structure (84a, 84b) and the gap are filled.

This invention is directed to system and methods for the oxygenation of the blood of a patient, comprising an extracorporeal blood circulation path adapted to be coupled to the patient's vascular system, and comprising apparatus for oxygenating blood flowing therein and withdrawing CO2 therefrom, wherein the flow rate of blood flowing in said extracorporeal blood circulation path does not exceed ⅖ of the patient's blood flow. The extracorporeal blood circulation path preferably comprise a cartridge including an oxygenator and at least one cannula.

A device for substance exchange between a first medium, in particular blood, and a second medium, in particular a gas/gas mixture, includes a housing element in which there is arranged a hollow-fiber bundle containing substance-permeable hollow fibers which extend axially between the axial ends of the housing element and at their respective axial end region are potted with a potting compound, at least among one another, and around which the first medium can flow and through which the second medium can flow. Also, a method for producing the device is provided.

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.