This disclosure provides for the application of a multi-disciplinary analysis of information sources to draw novel conclusions that result in new methods to diagnose, prevent or treat COVID-19. COVID-19 appears to be an extremely complex disease, encompassing three critical aspects at least: a viral infection, an immune system disorder, and a cardiovascular/pulmonary/renal disease with significant coagulation system dysregulation. This disclosure principally focuses on the design and methods of use of a combinatorial apparatus that addresses critical needs to treat patients with COVID-19, especially those at high risk of, or experiencing, adverse effects of COVID-19 infection, including but not limited to kidney function support, supplemental oxygen administration, correction of cardiovascular dysfunction, and removal or modification of deleterious molecules or agents from or in a patient's blood, including virus particles or molecular components thereof. Applications of the combinatorial device for disease management other than for use with respect to COVID-19 are also described.

Introduced here are pressure-mitigation apparatuses able to mitigate the pressure applied to a human body by the surface of an object. A controller device can be fluidically coupled to a pressure-mitigation device that includes a series of selectively inflatable chambers. When a pressure-mitigation device is placed between a human body and a surface, the controller device can continuously, intelligently, and autonomously circulate air through the chambers of the pressure-mitigation device. As further discussed below, the controller device may cause the chambers to be selectively inflated, deflated, or any combination thereof. Such an approach is useful in a variety of contexts. For example, pressure-mitigation apparatuses may be used to improve treatment of patients suffering from respiratory illnesses and patients who are partially or completely immobilized for extended durations (e.g., as part of a medical procedure).

The present invention provides a method, system, and apparatus that can substantially reduce the recirculation of venovenous extracorporeal membrane oxygenation (VV ECMO) associated with the two-site, single-lumen cannulation approach. Actively-controlled flow regulators comprising balloon, occluder and reservoir can be individually or collectively equipped on the drainage and/or infusion cannulas to accomplish the goal of maximizing VV ECMO support efficacy. Three specific embodiments are introduced to illustrate the practical enforcement of the proposed blood flow control in reference to the heart rhythm, aiming at achieving the maximal reduction of oxygenated blood flow recirculating back to the VV ECMO circuit.

The invention relates to a cannula (1) for injecting a fluid (F1) into a body cavity (5), comprising: a main lumen (LP) for the fluid to flow in a first direction; an accessory reperfusion lumen (LA) comprising an outlet (20′) for discharging the fluid in a second direction; and a device for positioning the cannula in the cavity, the device comprising a stop (41) which can move along an auxiliary lumen (LX) and be deployed in the cavity in order to lock the cannula in position in the cavity,
the outlet (30′) of the auxiliary lumen being arranged at a distance (d) from the outlet (20′) of the accessory reperfusion lumen such that when the cannula is locked in position in the cavity, the outlet (20′) of the accessory reperfusion lumen (LA) is oriented in the cavity such that the collected fluid is discharged in the second direction.

The present invention relates to a system (5) for temperature management for patients in stationary and mobile ECLS and/or ECMO therapy, with at least one disposable (7) and a fluid circuit (9), wherein the disposable (7) comprises at least one reservoir (10) or bag provided with at least one supply line (12) and a drain line (14), further provided at least one pumping unit element (11) as part of the disposable (7), by means of which liquid in the reservoir (10) or bag can be pumped through the fluid circuit (9).

Furthermore, the present invention relates to a disposable (7) for such a system (5).

The present disclosure provides for a cannula and balloon system for extracorporeal membrane oxygenation. The system may comprise one or more cannula, one or more insertion mechanism, and one or more balloon cuff. The method may comprise venous-venous or venous-arterial insertion into one or more blood vessels or chambers of the heart. The balloon cuff may allow fluid flow to avoid oxygenated blood restriction to a region of the body for the cannula insertion duration. One or both the balloon cuff and dual cannula may prevent occlusion, recirculation, and mixing of oxygenated and deoxygenated blood. When there is a dual cannula, the cannula may comprise a reinfusion cannula and a drainage cannula. A reinfusion cannula may bypass one or more chambers of the heart. When the system comprises more than one cannula, the cannulae may be joined via a cannula connection mechanism.

A display apparatus for a user interface of a medical instrument avoids erroneous input of numerical values when a user inputs information. A display apparatus includes a numerical value information input section, a selectable target information display section, and a target selection section. A plurality of the setting information selection sections are displayed to be associated with corresponding selectable target information, and a plurality of pieces of selectable target information are arranged so as to be adjacent to each other based on a same standard. The numerical value information input section corresponding to the selected target selection section is displayed simultaneously on a same screen. A range of the selectable target information is changed visually and displayed in response to the numerical value information which is input to the numerical value information input section.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 4 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more albumin dialysis modules configured to perform albumin dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees.

Disclosed is an artificial heart and lung apparatus (100) that can be connected to a patient (P), and transfers removed blood to a human body via a roller pump (120), the system including: the roller pump (120); a blood removal line (101) which transfers removed blood to the roller pump (120); a first blood transfer line (104) that transfers blood, which is transferred from the roller pump (120), to the human body; a blood removal rate sensor (111) that is provided in the blood removal line (101); and a control unit (140), in which the control unit (140) performs control such that a blood transfer rate of the roller pump (120) is in a specific range with respect to a blood removal rate measured by a blood removal rate sensor (111).

The invention relates to a portable gas exchange device for gas exchange of at least one gas from a liquid to a fluid. The gas exchange device comprises a first gas exchange section, for passage of a fluid, and a second gas exchange section for passage of a liquid enriched with a first gas, wherein the fluid has a lower concentration of the first gas than the liquid. A pumping system for transporting a first fluid with a lower concentration of a first gas in the first gas exchange section, in particular in a first fluid circuit, is also configured in the gas exchange device. In a mixing chamber configured in the gas exchange device, the first gas exchange section and the second gas exchange section adjoin one another via a wall designed such that at least the first gas can pass through. A housing serves as the common receptacle at least of the pumping system and the mixing chamber.