The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

A removable pressure sensor assembly senses a pressure in an elastically deformable tube conveying blood in an extracorporeal circulator. The assembly includes a main body portion 31 and a pressure measurement element 40 disposed in main body portion 31. Main body portion 31 has a base portion 32 with a tube mounting recessed portion 34 such that an intermediate part of a tube 11 is removably fitted such that tube 11 is elastically deformed. Pressure measurement element 40 is exposed to tube 11 so that it measures a pressure of blood inside tube 11. A lid portion 33 holds tube 11 inside tube mounting recessed portion 34 by selectably closing recessed portion 34 of the base portion. Tube mounting recessed portion 34 has a rectangular cross section, and a width L of the rectangular cross section is set to be smaller than an external dimension D of tube 11.

The present invention provides a hollow fiber membrane oxygenator comprising a housing comprising a blood flow path; a blood inlet port and a blood outlet port disposed in the housing so as to allow blood to flow through the blood flow path; a gas exchange part comprising a bundle of a plurality of hollow fiber membranes disposed in the blood flow path, a gas inflow port and a gas outflow port provided in the housing so as to allow an oxygen-containing gas to flow through lumens of the hollow fiber membranes, and a gas temperature control part for adjusting the temperature of a gas flowing through the lumens of the hollow fiber membranes.

A polysulfone-urethane copolymer is disclosed, which can be used as a membrane polymer, e.g., a matrix polymer, a pore forming agent, or both, while enhancing a membrane's blood compatibility. Methods are disclosed for forming the copolymer and incorporating the copolymer in membranes (e.g., spun hollow fibers, flat membranes) and other products.

A percutaneous catheter is disclosed through which blood passes. The percutaneous catheter having a catheter tube including a first tube and a second tube, the second tube being in fluid communication with the first tube, the first tube having an inner diameter greater than an inner diameter of the second tube, and wherein the first tube is more flexible than the second tube.

A system and method for enhancing transport of matter between two media. The system includes a membrane separating the two media wherein the first media contacts at least one surface area of the membrane. Further included is a transducer configured to direct acoustic energy into the first medium proximate the at least one surface area of the membrane. In this manner, the system accelerates transport of the matter from the first to the second media.

The device for blood oxygenation includes a gas exchange chamber with passage openings. One side the chamber is connected in a gas-tight manner with the expansion tank feeding the gas mixture containing oxygen to the chamber, having the inlet opening of gas mixture from the feeding installation. The other side of the chamber is connected in a gas-tight manner with the gas mixture discharging tank, having the outlet opening of gas mixture. The inner part of the chamber has a membrane as a capillary bundle permeable to gas mixture particles and non-permeable to blood particles, ends of which are anchored in the passage openings. The capillary bundle is tensed with a tension force and is parallel to the longitudinal axis of the chamber and to each other, or are arranged spirally. The side wall of the chamber has at least one inlet/outlet opening.

The present invention relates to a method for combined administration of carbon monoxide (CO) to an ex-vivo fluid and monitoring of the carbon monoxide administration, said method comprising: (i) generating CO by reacting a CO releasing molecule (CORM) with a release triggering molecule; (ii) administering CO to an ex-vivo fluid by contacting the ex-vivo fluid with the CO generated in step (i) via a gas-permeable membrane; (iii) analyzing carbon monoxide and/or a carbon monoxide marker after administering in step (ii) CO to the ex-vivo fluid by complementary monitoring techniques; (iv) adjusting the CO administration based on the analysis of the carbon monoxide or the carbon monoxide marker carried out in step (iii), if necessary. It furthermore relates to an extracorporeal circuit system for use in the method of the invention.

The invention relates to a holding means for holding an oxygenator and a blood pump. The holding means is characterised by a frame that can be connected with a carrying case housing in a torque-proof way for fitting the oxygenator and the blood pump relative to each other, wherein the frame has a frame section for connection with the oxygenator in a torque-proof way and another frame section for connection with the blood pump in a torque-proof way.

Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.