An extracorporeal blood circulation management device having an oxygenator accurately determines oxygen consumption by the target person and oxygen delivery by the oxygenator. Oxygenation-related parameter values in the blood are determined at regular intervals. An in-body passing time (a cycle time for a particular volume of blood to pass from input sensors to output sensors) is determined. Parameter values separated by the in-body passing time are selected as comparison targets to evaluate oxygenation consumption of the target person. An oxygenator unit passing time is determined. Parameter values separated by the oxygenator unit passing time are selected as comparison targets to evaluate oxygenation delivery of the oxygenation unit.

The present disclosure relates to a system (1) for carbon dioxide [CO2] removal from the circulatory system of a patient (3), comprising a medical device (5) for providing extracorporeal lung assist [ECLA] treatment to the patient (3) through extracorporeal removal of CO2 from the patient's blood, at least one control unit (22A-22C) for controlling the operation of the medical device (5) so as to control a degree of CO2 removal obtained by the ECLA treatment, and a bioelectric sensor (7) for detecting a bioelectric signal indicative of the patient's efforts to breathe. The at least one control unit (22A-22C) is configured to control the operation of the medical device (5) based on the detected bioelectric signal.

A heat exchanger for a blood circulation circuit includes a hollow fiber membrane layer having a plurality of laminated hollow fiber membranes 31. Each of the hollow fiber membranes 31 has a barrier layer 5 having a hydrogen peroxide barrier property, and the barrier layer 5 has an oxygen permeability coefficient of 6 cc.Math.cm/m.sup.2.Math.24 h/atm or less at 25 C.

A heat exchanger for a blood circulation circuit comprises a hollow fiber membrane layer having a plurality of hollow fiber membranes, and a fixing portion fixing both end portions of the hollow fiber membranes from outsides of the hollow fiber membranes. The fixing portion mainly contains polyurethane, and each of the hollow fiber membranes has a heat conductive layer containing high density polyethylene, and an adhesion layer provided on an outside of the heat conductive layer, bonded to the fixing portion, and mainly containing a modified polyolefin resin.

Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, a second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.

Disclosed is a method for treating a renal condition by loco-regional perfusion of one or both of a patient's kidneys (1810). A closed circuit may be formed with a perfusion catheter (1822) positioned in the renal artery of the kidney, a recovery catheter (1824) positioned in the renal vein of the kidney, and an external membrane oxygenator (1820) disposed therebetween. A perfusate containing, for example, a drug may be circulated through the closed circuit while isolating the closed circuit from the patient's systemic circulation.

An apparatus for removing CO from blood, the apparatus including: a housing configured to house blood obtained from a body of a subject within an interior of the housing; a plurality of gas-permeable tubules disposed within the interior of the housing; an optical intrusion coupled to the housing and configured to project into the housing, the optical intrusion configured to transmit light into the interior of the housing; and a light source optically coupled to the optical intrusion, the light source being configured to emit light which is coupled via the optical intrusion into the interior of the housing such that the emitted light interacts with the blood from the body of the subject.

A method and system for performing transseptal extracorporeal membrane oxygenation is disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. A first portion of the catheter system can remove blood from the patient, in some examples near the inferior vena cava. A second portion can return oxygenated blood to the patient, through the transseptal puncture and into the aorta.

An oxygenator and method for oxygenating blood. The oxygenator includes a housing, an oxygenation chamber, and elongated gas permeable conduits that extend across the oxygenation chamber. The blood flow enters and contacts with exterior surfaces of the conduits and exits the oxygenator to transfer of oxygen from within the conduits to the blood flow and transfer carbon dioxide from the blood flow into the elongated gas permeable conduits. The housing includes a gas inlet and is configured to distribute a gas flow received through the gas inlet to the elongated gas permeable conduits so as to a first portion of the gas flow flows through a first set of the elongated gas permeable conduits in a first direction and a second portion of the gas flow flows through a second set of the elongated gas permeable conduits in a second direction that is opposite to the first direction.

A blood pump is disclosed. The blood pump apparatus is arranged to provide pulsatile flow, and comprises a flexible inner cylindrical duct providing a blood flow region, and an outer cylindrical duct arranged to surround the inner cylindrical duct and arranged to accommodate a pumping fluid. In the pump the inner cylindrical duct is described as comprising a blood inlet for receiving blood into the region, a blood outlet for passing blood out from the blood flow region and a passageway therebetween. There is also described the feature of the inner duct comprising a non return valve at the blood inlet and a non return valve at the blood outlet, the outer cylindrical duct having a fluid port for a pumping fluid, and a pump device arranged to cyclically deliver and withdraw pumping fluid to the fluid port thereby cyclically compressing and expanding the flexible inner cylindrical duct urging blood through the blood flow region and delivering a pulsating blood flow through the blood outlet.