A system (20) including a heater/cooler module (22) to heat/cool a first fluid in a primary circuit (28), a heat transfer fluid circuit (24) to provide a second fluid to a target device (38) to heat/cool the target device (38), and a heat exchanger (26) including at least part of the primary circuit (28) and at least part of a secondary circuit (36) through which the second fluid flows to facilitate heat transfer between the first fluid and the second fluid. The primary circuit (28) and the secondary circuit (36) are separate circuits and the first fluid and the second fluid remain separated in the system. Also, the system is modular, such that the elements can be stacked to increase heating/cooling capability and/or to increase the number of heating/cooling channels, and the system is compatible with portable applications, such as ambulance, aircraft, and helicopter applications, and with battery opera-tion and/or the use of uninterruptible power supplies.

A portable, patient-wearable perfusion system includes a patch configured to cover at least a portion of a biological tissue graft implanted within a defect in a patient, a perfusion assembly configured to be worn or carried on the patient, and arterial and venous cannulas. The arterial and venous cannulas are configured to yield a closed fluid circuit for the perfusate to circulate through the graft. The patch includes a first sensor for detecting a first parameter relating to a physiologic state of the biological tissue graft. The perfusion assembly includes a reservoir for a perfusate, a pump, and a controller operatively coupled to the sensor. The controller is configured to operate the pump to control the physiologic state of the tissue graft based on data regarding the first parameter. The portable-patient wearable perfusion system may be used to preserve the implanted graft until the body naturally vascularizes the graft.

A device includes a housing, a gas inlet, a gas outlet, a liquid inlet, a liquid outlet, and one or more gas exchange units within the housing. Each gas exchange unit includes a gas channel in fluid connection with the gas inlet and with the gas outlet and a first liquid channel in fluid connection with the liquid inlet and with the liquid outlet. The first liquid channel is positioned adjacent to the gas channel and is separated from the gas channel via a first gas-permeable membrane. The first gas-permeable membrane is connected to a rigid substrate system so that the first gas-permeable membrane extends beyond a first edge of the rigid substrate system. The device further includes an oscillator to induce oscillation in the rigid substrate system and thereby in the first gas-permeable membrane.

A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

An extracorporeal blood gas exchange device has a bloodstream area for guiding a bloodstream, a gas-carrying area for guiding a gas flow, and a membrane, which forms a gas-liquid barrier between the bloodstream and the gas flow, and which further makes possible the transfer of carbon dioxide of the bloodstream into the gas flow. The device further has at least one measuring cuvette, which is separated from the bloodstream area at least partially by the membrane, so that carbon dioxide of the bloodstream can pass over into the measuring cuvette. The device has an optical measuring unit, which is configured to measure a carbon dioxide partial pressure present in the measuring cuvette.

A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

Intravascular membrane oxygenator catheter systems and methods are disclosed, along with methods of making and using the same. A catheter system includes a catheter shaft having a wall that extends from a proximal end to a distal end along a longitudinal axis to define a lumen, a plurality of hollow fiber membrane loops each having a proximal portion positioned within the lumen of the catheter shaft and a distal portion extending beyond the lumen of the catheter shaft, the hollow fiber membrane loops are nonporous with solid walls; a pneumatic source in pneumatic communication with the hollow fiber membrane loops. The pneumatic source provides a gas containing oxygen at a pressure sufficient to cause a diffusive flux of the gas containing oxygen from an interior of the hollow fiber membrane loops to a fluid exterior to the hollow fiber membrane loops in a region of interest of a subject.

Adaptors, cannulas, caps, tube couplers, and systems thereof provide endovascular access through an established ECLS system. Adaptors having curved or angled shafts navigate right angle side ports of standard bypass cannulas and permit hemostatic introduction and direction of an intervention device to the axial flow path of the cannula lumen and bypass system. A modified cannula having an angled side port is also provided for use as an arterial cannula. A cap having an occluding surface may be inserted into the angled side port to prevent blood from stagnating in the angled side port. A tube coupler is also provided having an access port, such as an angled access port, and may be spliced into an established bypass system for vascular access point. Multiple couplers can be used to provide multiple access points. The adaptors and occlusive cap are interchangeable with each other and with secondary circuits.

Described herein are systems, devices, and methods for an extracorporeal, artificial, placenta. In some embodiments, an artificial placenta and amniotic bed system may comprise a control unit, a gas delivery unit, a gas exchange unit or membrane oxygenator, a fluids delivery unit, an amniotic fluid bed, and a human machine interface. In some embodiments, the artificial placenta and amniotic bed systems, devices, and methods described herein may improve survival rates and minimize long-term disabilities in preterm, gestational-age, newborns. In some embodiments, the extracorporeal systems, devices, and methods comprise an artificial network through which oxygen and nutrient-rich blood may flow into a fetus (residing in an amniotic fluid bed), while carbon dioxide and wastes may be removed, thus re-establishing a form of intrauterine placental circulation.

A cold and heat exchange system for a cardiac surgical operation with cardiac arrest, comprising: an ice water tank (15), a primary circulation water tank (11), and a secondary circulation water tank (16). Side walls of the primary circulation water tank (11) and the secondary circulation water tank (16) are each provided with an overflow orifice which is connected to the ice water tank (15) through a circulation pipe (14). A first roller pump (12) is mounted on a first hose (13). A second roller pump (18) is mounted on a second hose (17). The primary circulation water tank (11) is mounted on a first loop (5) and a second loop (6). The secondary circulation water tank (16) is mounted on a third loop (1).