The disclosed device, systems and methods relate to a novel catheter, system and methods. Exemplary embodiments comprise a plurality of lumens and balloons for insertion into the aorta and vena cava.

An extracorporeal system for lung assist includes a housing having a blood flow inlet in fluid connection with a pressurizing stator compartment within the housing. A fiber bundle compartment within the housing is above and in fluid connection with the pressurizing stator compartment via a flow channel formed within the housing and extending from the pressurizing stator compartment to an inlet manifold of the fiber bundle compartment. A blood flow outlet in is fluid connection with an outlet man fold of the fiber bundle compartment. The blood flow inlet extends through the housing parallel to a plane of rotation of an impeller in the pressurizing stator compartment. The blood flow inlet turns to deliver blood into a central portion of the impeller. A has inlet is in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers of a cylindrical fiber bundle positioned within the fiber bundle compartment. A gas outlet is in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.

Described is a blood processing apparatus with a blood flow path and a heat exchanger fluid flow path overlapping the a heat exchanger chamber, in which the blood flows generally from a first end to a second end of the blood processing apparatus, and the heat exchanger fluid flows generally from the second end to the first end. Such counter or countercurrent flow improves heat transfer between the blood and the heat exchanger fluid. The blood processing apparatus includes a housing, a blood inlet, a heat exchanger fluid inlet and a heat exchanger fluid outlet, a heat exchanger core, a cylindrical shell having an annular shell aperture, a blood flow distributor, and a central chamber in fluid communication to a fluid flow distributor.

The present invention relates to the field of stem cells and their use in processing ex vivo samples (e.g. blood samples). More specifically, the present invention relates to the use of mesenchymal stem cells in ECMO.

The blood circulation circuit 1 includes: a blood removal line 2 that removes venous blood; a blood storage tank 4 that is connected to the blood removal line 2 and stores the blood that has flowed through the blood removal line 2; a negative pressure adjusting device 6 that adjusts a negative pressure inside the blood storage tank 4; a blood pump 5 that pumps the blood in the blood storage tank 4; an artificial lung 7 that performs gas exchange of the blood pumped from the blood pump 5; and a blood collecting line 3 that is connected to the blood storage tank 4 and sucks blood from a surgical site by the negative pressure in the blood storage tank 4.

An oxygenator includes: a housing; a bubble-removing hollow fiber membrane layer removing a bubble; a gas-exchanging hollow fiber membrane layer exchanging a gas with blood; and a discharge port to discharge the bubble removed by the bubble-removing hollow fiber membrane layer to the outside of the housing. The oxygenator further includes a gas permeable portion that is arranged between the discharge port and an end portion of the bubble-removing hollow fiber membrane layer, is formed by a member having gas permeability, and allows passage of the bubble removed by the bubble-removing hollow fiber membrane layer without allowing passage of plasma leaking through the bubble-removing hollow fiber membrane layer. A plasma capture chamber that captures the plasma leaking through the bubble-removing hollow fiber membrane layer is formed between the end portion of the bubble-removing hollow fiber membrane layer and the gas permeable portion.

A system for extracorporeal organ support can include an organ chamber and a cross-circulation circuit. The organ camber can be configured to hold an extracorporeal organ. The cross-circulation circuit be configured to connect the extracorporeal organ and a host organism to maintain the extracorporeal organ by perfusing veno-arterial-venous (V-AV) blood through the extracorporeal organ and the host organism, wherein physiologic stability of the host organism is maintained.

An oxygenator (10) for an extracorporeal ventilation system comprises a gas passage and a blood passage arranged to allow gas exchange of an oxygenation gas supply with blood via a gas-blood interface (34). The gas passage leads from a gas inlet zone (28) via the gas-blood interface (34) to a gas exhaust zone (40). The blood passage leads from a blood inlet (12) via the gas-blood interface (34) to a blood outlet (14). The oxygenator comprises a supply gas distribution arrangement (26, 28A, 28B). This allows the oxygenation gas supply to be modulated differently for different interface regions of the gas-blood interface. The oxygenator can be used to remove or reduce the formation of gaseous microemboli bubbles.

A combined bio-artificial liver support system, includes branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end of which is set as a blood input end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end.

The present invention provides a method, system, and apparatus that can substantially reduce the recirculation of venovenous extracorporeal membrane oxygenation (VV ECMO) associated with the two-site, single-lumen cannulation approach. Actively-controlled flow regulators comprising balloon, occluder and reservoir can be individually or collectively equipped on the drainage and/or infusion cannulas to accomplish the goal of maximizing VV ECMO support efficacy. Three specific embodiments are introduced to illustrate the practical enforcement of the proposed blood flow control in reference to the heart rhythm, aiming at achieving the maximal reduction of oxygenated blood flow recirculating back to the VV ECMO circuit.