A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.

A percutaneous catheter for an extracorporeal blood circulator has a tubular reinforcement body comprised of a plurality of wires braided in a reticulated manner. The braided wires include first wires wound in a first helical direction and second wires wound in a second helical direction crossing the first wires to define regular gap portions. A portion of the first and second wires are deviated from the helical directions to enlarge a selected gap portion into a first opening portion. A resin layer coats the reinforcement body and includes a second opening portion coincident with the first opening portion to form a side hole for fluid communication between an interior lumen and an exterior of the catheter. A continuous reinforcement is provided between longitudinal ends of the tubular reinforcement body including a longitudinal region of the side hole.

The present invention generally relates to a process suitable for extracorporeal lung support. The process comprises contacting blood with a dialysis liquid separated by a semipermeable membrane. Oxygen is introduced into blood and/or into the dialysis liquid prior to contacting blood and dialysis liquid being separated by the semipermeable membrane. The process is versatile and allows for blood oxygenation as well as removal of at least one undesired substance occurring in the blood, selected from carbon dioxide, bicarbonate and hydrogen cations, from blood. Thereby, the present invention takes advantage of the Haldane effect in the extracorporeal contacting step. The undesired substance can be efficiently transported across a semipermeable membrane to the dialysis liquid. In contrast to extracorporeal carbon dioxide removal methods of the prior art (ECCCbR), the present invention employs a versatile dialysis liquid that allows to adjust the pH and buffering capacity of the dialysis liquid, to add fluids to the dialysis liquid and/or to the blood and to remove substances from the blood in the extracorporeal circuit, depending on the conditions and needs. The present invention also provides regeneration and recycling of the dialysis liquid, and thus for its repeated use. The present invention is suitable for treating human or animal subjects suffering from lung failure or lung disorders.

The disclosed device, systems and methods relate to a novel catheter, system and methods. The various catheter implementations are for use in cardiopulmonary resuscitation and other medical or surgical conditions that require emergency restoration of cerebral and cardiac blood supply. The catheter or catheters have one or more lumens and balloons. Two catheters connected to a control unit can be disposed within the body to occlude and perfuse a region of the circulatory system.

A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.

A heat exchanger has a hollow fiber membrane layer comprised of a plurality of hollow fiber membrane conduits each of which has a hollow portion allowing a heat medium to pass therethrough. The conduits are derived by winding a base cord of the hollow fiber membrane onto a cylindrical body. The winding follows a generally helical trajectory around the longitudinal axis of the cylindrical body with a plurality of continuous round trips from the first end to the second end and turning back at each respective end, wherein each round trip completes a number of circumferential revolutions N, wherein N is greater than or equal to one, and wherein N is less than two.

A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing.

A device hereof includes a first volume for flow of a first fluid therethrough, a second volume for flow of a second fluid therethrough, a membrane separating the first volume from the second volume, which is permeable to transfer/exchange of at least one component between the first volume and the second volume and a drive system or actuator system to induce oscillation in the membrane.

A tube clamp for an extracorporeal circulator recognizes various abnormal situations of the tube clamp and notifies a user. The tube clamp has a lid sensor, a tube sensor, and a plunger sensor. In a case where any one of detection of the closure of a lid portion via the lid sensor, detection of the mounting of a tube via the tube sensor, and detection of the movement of a plunger via the plunger sensor is not obtained despite the fact that there is an instruction for blocking the tube, it is determined that the blocking is abnormal. In a case where the three states including the closed state, the mounting state, and the movement state are detected despite the fact that there is no instruction for blocking the tube, it is determined that the tube is erroneously blocked. Such abnormal situations are notified to a user via an alarm.

An oxygenator unit adapted for use in an extracorporeal blood treatment device. The oxygenator unit includes an oxygenator having a gas inlet and a supply line for conducting a gas provided at the gas inlet, the supply line being connectable to a source of a pressurized gas containing oxygen, wherein the oxygenator unit further includes a pressure relief valve provided in the supply line upstream of the oxygenator, the pressure relief valve adapted to release pressure exceeding a predetermined pressure value from the supply line, thereby preventing a critical overpressure in the oxygenator.