Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.

The invention relates to a heat exchanger tube (1) which is a component of a heat exchanger of an oxygenator. The heat exchanger tube (1) comprises a tube body (2) consisting of thermoplastic polyurethane (PTU). The tube body (2) has a Shore hardness of greater than 60 D. This results in a heat exchanger tube optimised for use in a heat exchanger of an oxygenator.

Disclosed herein are methods of treating venous thrombosis and vascular inflammation through administration of carbon monoxide and/or a carbon monoxide releasing molecule. Also disclosed herein are devices capable of releasing carbon monoxide for the purpose of treating microvascular, arterial and venous thromboembolism and/or inflammation.

A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.

An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas levels; and a feedback controller receiving the blood CO.sub.2 or O.sub.2 signal and outputting a control signal to control gas flow and/or blood flow.

Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.

A fluid treatment method, a fluid treatment device, a cycle separation device, a cycle treatment system, a medical device, and a computer readable storage medium are provided. The fluid treatment method intercepts the target substance in the fluid, and cyclically enriches the target substance in the enrichment pipeline. In a cycle enrichment mode, the flow rate at the inlet is equal to that of the outlet in the enrichment pipeline so as to dynamically balance a total amount of the fluid in the enrichment pipeline. The present disclosure treats the fluid sustainably, collect particular components of the fluid, and a fluid discharged from the first outlet of the enrichment pipeline is introduced into the treatment module or is returned to an original system. The present disclosure effectively avoids continuous loss of beneficial components when filtering out harmful components in the process of component separation/exchange of the fluid through membrane separation.

A device for the continuous monitoring of blood characteristic quantities in an external cardiovascular supporting circuit, said circuit including a venous line which conveys blood from the patient to an oxygenator, and along which at least one pump is arranged, and an arterial line which returns blood from the oxygenator to the patient, where said oxygenator comprises at least one blood inlet port connected to said venous line and at least one blood outlet port connected to said arterial line, at least one inlet channel and at least one outlet channel of a work gas intended to supply oxygen to the blood and/or to remove carbon dioxide from the same.

The oxygenator (10) of organic fluids comprises a container body (20); a first aperture (21) for the entry of oxygen and a second aperture (22) for the exit of an exhausted gas; a third aperture (23) for the entry of an organic fluid to be oxygenated and a fourth aperture (24) for the exit of an oxygenated organic fluid; an oxygenation chamber (30) to oxygenate the organic fluid to be oxygenated, defined inside the container body (20); and a mass (31) of capillary fibers (32) which are impermeable to liquids and porous to gases, disposed so as to be lapped by the organic fluid inside the oxygenation chamber (30), parallel to each other in a first direction (X).

Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.