A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

Corporeal and extra-corporeal filtration and oxygenation devices include multi-chambered structures having a semi-permeable membrane between two chambers for creating differentials to extract waste from and/or add oxygen to blood flowing through the devices. A bio-modified material covers multiple surfaces of the devices which encounters blood to reduce blood contact with polymeric surfaces. Blood contact with polymeric surfaces causes a chemical cascade which in turn induces an inflammatory response in a patient's body. The filtration and oxygenation devices, and methods of installing and using the devices, reduce the frequency and severity of the inflammatory.

A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing.

An extracorporeal gas exchange device includes a housing, a rigid shaft rotatable within the housing, a plurality of agitation mechanisms positioned on the rigid shaft, and a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between fluid flowing within the housing and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers are positioned radially outward from the plurality of agitation mechanisms. The rotational speed of the rigid shaft is adjustable independent of the flow rate of fluid through the housing.

A compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.

An extracorporeal blood treatment system including a gas exchange module operatively associated with a gas supply unit and optional pump for removing CO.sub.2 from blood. The gas exchange module includes a plurality of short conduits that are uniquely configured and arranged in a gas exchange mat to for efficient CO.sub.2 diffusion under conditions of low blood flow.

The present invention provides methods of administering nitric oxide (NO) to a patient, the method comprising delivering nitric oxide-containing gas directly into arterial or arterialized blood. The methods of the present invention may be used in the treatment or prevention of a variety of diseases and disorders responsive to nitric oxide, including those resulting from ischemia or hypoxia.

A veno-arterial extracorporeal membrane oxygenation system includes a dual lumen drainage cannula configured for withdrawing blood from a patient's vasculature in a manner that provides a perfusion of oxygenated blood with reduced carbon dioxide content while unloading the left ventricle, with two points of access to the patient's vasculature. The dual lumen drainage cannula has a first drainage tube and a second drainage tube co-axially aligned with the first drainage tube. The first and second drainage tubes are fluidly coupled to a connector. A blood pump having a pump inlet is configured for fluidly connecting with the connector, while an oxygenator having an oxygenator inlet is configured for fluidly connecting with a pump outlet. An infusion cannula is configured for fluidly connecting with an oxygenator outlet for infusing oxygenated blood into a patient's bloodstream.

A substance exchange device for intracorporeal use includes a cavity for receiving blood having at least one blood inlet and at least one blood outlet, a substance exchange membrane adjoining the cavity, a supply duct for supplying an exchange fluid to the substance exchange membrane, a blood pump arranged within the cavity and a drive unit for the blood pump. The blood pump is configured to pump blood in a direction from a blood inlet to a blood outlet of the cavity. The drive unit includes a turbine, which is connected to the supply duct and may be driven by an exchange fluid supplied via the supply duct, where the turbine includes at least a rotor coupled to the blood pump and a stator (turbine nozzle) arranged upstream of the rotor.

A heat exchanger for an oxygenator comprises multiple tube sections, each having a longitudinal tube axis, wherein the tube sections are disposed as a bundle having a longitudinal bundle axis, and the tube sections are connected to each other in at least one connecting section of the bundle by joining by way of chemical and/or physical bonded joints. A method for producing the heat exchanger is also provided.