An integrated on-line monitoring and thermostatic heating apparatus for a bioartificial liver device, the apparatus including a blood inlet, a blood pump, an arterial drip chamber, a bioreactor module, a venous drip chamber, and a blood reinfusion port which are connected in sequence. The bioreactor module includes a thermostatic water tank and a bioreactor disposed in the thermostatic water tank. The bioreactor includes a container, and a first partition and a second partition which are disposed in the container. The first partition and the second partition separate the container into three independent parts, that is, a plasma separator, an oxygenator, and a reactor. The plasma separator and the oxygenator are connected through an external connection pipe. The external connection pipe is equipped with a separation pump. The second partition includes a communication hole, and the reactor and the oxygenator are connected through the communication hole.

A combination kidney and liver dialysis system and method provides a portable, lightweight hemodialysis device that removes uremic toxins, hepatic toxins, water, and impurities from the blood. The method comprises separating the blood into a plasma portion and a cellular portion, immediately returning the cellular portion to the body, providing large volumes of replacement fluids, diluting the plasma portion with replacement fluids, and then manipulating the plasma portion of the blood to pass through hemoperfusion membranes, hemodiafiltration membranes, and extracorporeal membrane oxygenation membranes. Dialysis is performed on the plasma portion of the blood with an albumin dialyzer against an albumin dialysate and a high molecular weight cut off membrane. Dialysis is performed on the plasma portion of blood with a lipid dialysate comprising 10-30% lipid composition, and a high flux dialyzer. The system can also use any form of dialysis technology including hollow fiber, flat plate and microfluidic technology.

Systems and method for peripheral cannulation are provided. Systems include cannulas defining fenestrations that can be exposed or occluded by a cover slip to selectively expose fenestrations to blood flow in an artery or vein.

Systems and methods for perfusing a treatment solution into the blood stream of particular organs while isolating those organs from the systemic vasculature as a whole. By deploying both collection and supply catheters, some having balloons on their distal ends, to particular locations within the body, various organs can be isolated so that the treatment solution can be delivered directly thereto. By isolating the organs, any side effects that may occur from a systemic introduction of the treatment solution are avoided. The method may be used to isolate not just organs, but specific tumors within certain organs for oncology treatment.

An extracorporeal circuit for the decapneization of organic fluids includes a line for draining from a patient the organic fluid to be decapneized, a line for re-infusing the patient with the decapneized organic fluid, at least one pump group of the organic fluid arranged at least on the draining line, at least one decapneizer into which the drainage line enters and from which the re-infusion line exits, and a first sensor for detecting at least one input parameter of the organic fluid to be decapneized, the first sensor being mounted between the pump group and the decapneizer.

Gaseous nanobubbles are created and infused into the blood stream to therapeutic effect such as oxygenation. The nanobubbles may be created inside or outside of the patient, either during infusion or prior to infusion. CO2 is extracted from the blood to improve oxygen.

A gas supply control system for an oxygenator of an extracorporeal ventilation system is configured for connection to external gas supply ports for oxygen and nitrogen in the form of air and to create a supply gas output from oxygen and nitrogen. The gas supply control system includes two or more gas output lines and configured to supply the two or more gas output lines with the supply gas output. The flow rates through the gas output lines may be modulated differently.

A dual lumen cannula includes a first tube defining a return lumen and having a proximal end, a mid-portion and a distal end, wherein the distal end includes a return aperture. A second tube is coaxial with the first tube and has a proximal end and a distal end, wherein the distal end of the second tube is fixedly attached to the mid-portion of the first tube and wherein the distal end of the second tube includes a drainage aperture. A drainage lumen is defined by a space between the first tube and the second tube. A connector is attached to the proximal end of the second tube. The connector includes a reservoir for receiving a fluid from the proximal end of the second tube. The first tube extends through the connector and does not attach directly with the second tube at the connector, and the first tube remains substantially coaxial with the second tube throughout a length of the second tube.

A dual lumen cannula includes a first tube defining a return lumen and having a proximal end, a mid-portion and a distal end, wherein the distal end includes a return aperture. A second tube is coaxial with the first tube and has a proximal end and a distal end, wherein the distal end of the second tube is fixedly attached to the mid-portion of the first tube and wherein the distal end of the second tube includes a drainage aperture. A drainage lumen is defined by a space between the first tube and the second tube. A connector is attached to the proximal end of the second tube. The connector includes a reservoir for receiving a fluid from the proximal end of the second tube. The first tube extends through the connector and does not attach directly with the second tube at the connector, and the first tube remains substantially coaxial with the second tube throughout a length of the second tube.

A cannula device for the circulation of the blood in an artificial lung, includes: an aspiration lumen including at least one orifice permitting the aspiration of a volume of blood; an injection lumen including at least one orifice permitting the injection of a volume of blood, wherein the injection lumen and the aspiration lumen are held rigidly connected over at least a portion of their length, the lumens being sealed in relation to each other, the injection lumen having a deformable element, which is held on a portion of the distal end thereof, the deformable element having a first setting and a second setting, the change from the first setting to the second setting being effected by a modification of the diameter of the deformable element.