Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

Disclosed are an oxygenator and an extracorporeal membrane oxygenation device. The oxygenator includes a housing; an oxygenation chamber, arranged in the housing, and having a blood flow pipeline extend through a blood inlet and a blood outlet; a partition plate, arranged between the housing and the oxygenation chamber, the partition plate is arranged in a same direction as the upper end cover and divide the interior of the housing into a heat medium chamber and a gas chamber. The oxygenator combines the design of a heat medium chamber and a gas chamber to perform brand-new optimization design on a blood flow path, a gas pipeline and a heat medium pipeline of a membrane lung, so as to obtain the best hemodynamic performance, uniform distribution of internal flow fields and pressure fields, small flow retention zone, low blood flow resistance and high gas blood exchange efficiency and heat exchange efficiency.

Adaptors, cannulas, caps, tube couplers, and systems thereof provide endovascular access through an established ECLS system. Adaptors having curved or angled shafts navigate right angle side ports of standard bypass cannulas and permit hemostatic introduction and direction of an intervention device to the axial flow path of the cannula lumen and bypass system. A modified cannula having an angled side port is also provided for use as an arterial cannula. A cap having an occluding surface may be inserted into the angled side port to prevent blood from stagnating in the angled side port. A tube coupler is also provided having an access port, such as an angled access port, and may be spliced into an established bypass system for vascular access point. Multiple couplers can be used to provide multiple access points. The adaptors and occlusive cap are interchangeable with each other and with secondary circuits.

Introduced here are pressure-mitigation apparatuses able to mitigate the pressure applied to a human body by the surface of an object. A controller device can be fluidically coupled to a pressure-mitigation device that includes a series of selectively inflatable chambers. When a pressure-mitigation device is placed between a human body and a surface, the controller device can continuously, intelligently, and autonomously circulate air through the chambers of the pressure-mitigation device. As further discussed below, the controller device may cause the chambers to be selectively inflated, deflated, or any combination thereof. Such an approach is useful in a variety of contexts. For example, pressure-mitigation apparatuses may be used to improve treatment of patients suffering from respiratory illnesses and patients who are partially or completely immobilized for extended durations (e.g., as part of a medical procedure).

Introduced here are pressure-mitigation apparatuses able to mitigate the pressure applied to a human body by the surface of an object. A controller device can be fluidically coupled to a pressure-mitigation device that includes a series of selectively inflatable chambers. When a pressure-mitigation device is placed between a human body and a surface, the controller device can continuously, intelligently, and autonomously circulate air through the chambers of the pressure-mitigation device. As further discussed below, the controller device may cause the chambers to be selectively inflated, deflated, or any combination thereof. Such an approach is useful in a variety of contexts. For example, pressure-mitigation apparatuses may be used to improve treatment of patients suffering from respiratory illnesses and patients who are partially or completely immobilized for extended durations (e.g., as part of a medical procedure).

Introduced here are pressure-mitigation apparatuses able to mitigate the pressure applied to a human body by the surface of an object. A controller device can be fluidically coupled to a pressure-mitigation device that includes a series of selectively inflatable chambers. When a pressure-mitigation device is placed between a human body and a surface, the controller device can continuously, intelligently, and autonomously circulate air through the chambers of the pressure-mitigation device. As further discussed below, the controller device may cause the chambers to be selectively inflated, deflated, or any combination thereof. Such an approach is useful in a variety of contexts. For example, pressure-mitigation apparatuses may be used to improve treatment of patients suffering from respiratory illnesses and patients who are partially or completely immobilized for extended durations (e.g., as part of a medical procedure).

Aspects of the present invention relate to a blood perfusion reservoir device including a housing forming proximal and distal chambers, the housing having proximal and distal openings, a valve having a proximal end, a distal end and a length forming a lumen therebetween, the valve being positioned within the housing such that the proximal end passes through the proximal opening of the housing, the distal end passes through the distal opening of the housing, and the length passes through the proximal and distal chambers of the housing, wherein the valve is configurable between a first and second position, the first position forming a first flow path and the second position forming a second flow path, a filter reservoir having a frame with a filter media forming proximal and distal filter regions with a proximal opening, and positioned within the housing fixedly attached to the valve and surrounding a length of the valve, wherein the first flow path fluidly connects the proximal and distal openings, and the flow bypasses the proximal and distal chambers, the proximal and distal filter regions, and the second flow path fluidly connects the proximal and distal openings, and the flow passes through proximal and distal chambers and the proximal and distal filter regions.

Disclosed are devices and methods directed to oxygenators for use in extracorporeal circuits for supporting a fetus. An oxygenator for use with an extracorporeal circuit includes a housing defining a cavity therein and a gas exchanger disposed within the interior cavity. The cavity is configured to receive blood a fetus. The gas exchanger is configured to receive a sweep gas and further configured to contact the blood within the cavity, such that at least oxygen gas and carbon dioxide gas is permitted to diffuse between the blood and the gas exchanger.

A blood circulation system that can be connected to a human body is provided. The system may include a roller pump, a blood removal line through which blood removed from the human body flows to the roller pump, a blood transfer line that transfers blood, which is sent from the roller pump, to the human body, means for measuring a blood removal rate provided in the blood removal line to measure a blood removal rate parameter of blood flowing through the blood removal line and a control unit, wherein the control unit is programmed to control a blood transfer rate of the roller pump by controlling a rotational speed of the roller pump with a control signal, such that a transfer rate of blood flowing through the blood transfer line is synchronized with a removal rate calculated from the blood removal rate parameter.

A system for performing extracorporeal blood treatment of recovered blood can include a reservoir to receive a first portion of the recovered blood from a subject, an inline pump coupled the reservoir to regulate a flow rate of at least the first portion of the recovered blood, and an extracorporeal blood conditioner including at least one of an oxygenator to reoxygenate hemoglobin included in the recovered blood for at least intravenous delivery back to the subject or a temperature regulator configured to selectively control a temperature of the recovered blood.