The present invention relates generally to a pulmonary assist device comprising a housing having tapered inlets and outlets to distribute blood evenly over a fiber bundle. The fiber bundle has a relatively low packing density to prevent the formation of clots. The invention is adapted to be used with a pump or without a pump, in which the heart supplies the necessary blood flow. Moreover, the device can be used as a single module or as multiple modules arranged in parallel.

Extracorporeal life support (ECLS) systems, devices and methods wherein a portable ECLS device is used to deliver cardiovascular support to a humans or animal patient (or harvested organ(s)) during pre-hospital or inter-hospital transport.

An oxygenator apparatus for use in an extracorporeal circuit. The apparatus includes a housing and a membrane assembly disposed within the housing. The membrane assembly includes a first plurality of gas exchange elements disposed in a first zone and a second plurality of gas exchange elements disposed in a second zone. The second zone is arranged concentrically around the first zone. The first and second plurality of gas exchange elements are fluidly open along a body and fluidly separated along a distal end. The first zone is configured to be fluidly coupled to an oxygen source and the second zone is configured to be fluidly coupled to a negative pressure source. A blood flow path includes a generally radial flow through the first zone to add oxygen to the blood and the second zone to separate gaseous micro emboli from the blood through the plurality of gas exchange elements.

Gas exchange unit comprising an inlet that is acentrically slanted, and a method for producing a gas exchange unit.

A system for removing gaseous micro emboli from blood prior to oxygenation. The system including a module having a blood inlet, a blood outlet, and a port configured to provide atmospheric or sub-atmospheric pressures, and microporous hollow fibers situated in the module and fluidly coupled to the port to provide the atmospheric or sub-atmospheric pressures inside the microporous hollow fibers. The module is configured to receive the blood through the blood inlet such that the blood flows from the blood inlet to the blood outlet around outside surfaces of the microporous hollow fibers such that at least some of the gaseous micro emboli in the blood are drawn from the blood through the microporous hollow fibers by the atmospheric or sub-atmospheric pressures.

The present disclosure provides systems for controlling infusion of one or more supplements into blood received from a patient. The systems include at least one an extracorporeal circulatory support system including a pump, fluid conduits, and at least one a sensor configured to measure one or more parameters of the blood. The system also may include a fluid flow regulator coupled to the extracorporeal circulatory support system. The system receives measurement signals corresponding to parameters of blood from the at least one sensor and determines one or more target values for the parameters of blood based on a patient profile and/or the measurements. The system may control the fluid flow regulator to cause an infusion of at least one supplemental fluid from a supplemental fluid source into the blood.

Provided are photocurable resins comprising a poly(siloxane)-based copolymer together with a photoinitiator, and other optional ingredients such as a photocurable diluent, a photoabsorber, a photosensitizer, or a hydrophillic additive. Also provided are methods of stereolithographically printing a 3-D object from a disclosed resin. Also provided is an improved method for stereolithographically printing a 3-D object, the improvement comprising the use of a disclosed photocurable resin. Further provided is a 3-D microfluidic device such as an artificial lung prepared from a disclosed photocurable resin.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees.

Extracorporeal circuit devices that can be used for on-pump open-heart surgery to support surgical procedures such as coronary artery bypass grafting are described. In some embodiments, an oxygenator can include an integral pump. Such an integrated arrangement can advantageously provide an extracorporeal circuit with a lower overall volume than other conventional extracorporeal circuits.

Provided are a device and method for using bilirubin photoisomerization to reduce bilirubin interference with laboratory blood tests for other chemical analytes.