An extracorporeal blood cooling or heating circuit includes an intravenous catheter for withdrawing a patients blood coupled to a combined pump/heat exchanger device. One or more sensors are provided upstream and/or downstream of the pump/heat exchanger device for measuring pressure, temperature, fluid flow, blood oxygenation, and other parameters. A controller is operatively coupled to the pump/heat exchanger device and the one or more sensors to control the speed of the pump inside the pump/heat exchanger device and regulate the blood temperature by controlling the operation of the heat exchanger. The combined pump/heat exchanger device includes a housing having at least one inlet and at least one outlet, a pump portion defining a blood circuit inside the housing, and a heat exchanger portion contained within the housing for selectively heating or cooling the blood.

A system for lung assist includes a fiber bundle section including a fiber bundle housing defining a fiber bundle compartment therein, and a fiber bundle within the fiber bundle compartment. The fiber bundle housing includes a first interface on a second end of the fiber bundle housing opposite a first end thereof. The system further includes a base section having a housing including a pressurizing section including a pressurizing compartment and an interface section. The interface section includes an extending section which extends from a lateral end of the pressurizing section. The interface section includes a second interface formed on the extending section, which includes a releasable seal member configured to form a releasable sealing connection with the first interface of the fiber bundle section. The base section housing and the fiber bundle housing are separate elements connected by a releasable, sealing connection between the first and second interfaces.

Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

An artificial lung device includes: a housing which is formed in a tubular shape including both end portions closed, includes a blood inflow port and a blood outflow port, and is arranged such that a center axis of the housing is directed in a lateral direction; a hollow fiber body (gas exchanger) which is arranged in the housing and performs gas exchange with respect to blood while the blood flows from the blood inflow port to the blood outflow port; and a straightening frame (gas guide portion) by which a gas having flowed through the gas exchanger by the flow of the blood is guided to the gas exchanger again in the housing.

A combined bio-artificial liver support system, includes branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end of which is set as a blood input end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end.

The present disclosure concerns embodiments of multi-lumen cannulae that can be used in various different medical procedures. The multi-lumen cannulae can comprise an elongated body comprising multiple different ports that connect to various different sidewall lumens contained within the elongated body. The multi-lumen cannulae can also comprise a central lumen that extends through the entire elongated body and can be fluidly connected to the various different sidewall lumens. The multi-lumen cannulae can further comprise two balloons on an exterior of the elongated body, which can be used to isolate a right atrium of a patient's heart.

Apparatus (20) is provided for use with an extracorporeal membrane oxygenation (ECMO) or cardiopulmonary bypass (CPB) machine. The apparatus (20) includes a venous cannula (22), which has a proximal end (24) and a distal tip (26), and is shaped so as to define (a) a blood-drainage lumen (28) through the venous cannula (22), and (b) at or near the distal tip (26), one or more openings (30) between the blood-drainage lumen (28) and outside the venous cannula (22). A connector (36) is coupled to the proximal end (24) of the venous cannula (22) in fluid communication with the blood-drainage lumen (28), and is configured to be coupled to the ECMO or CPB machine. A fluid-tight distal balloon (38) is coupled to the venous cannula (22) near the distal tip (26) of the venous cannula (22). An external proximal balloon (40) is configured to be disposed outside a subject's body. A balloon-connection lumen (42) couples the distal balloon (38) in fluid communication with the external proximal balloon (40). Other embodiments are also described.

A veno-arterial extracorporeal membrane oxygenation system includes a dual lumen drainage cannula configured for withdrawing blood from a patient's vasculature in a manner that provides a perfusion of oxygenated blood with reduced carbon dioxide content while unloading the left ventricle, with two points of access to the patient's vasculature. The dual lumen drainage cannula has a first drainage tube and a second drainage tube co-axially aligned with the first drainage tube. The first and second drainage tubes are fluidly coupled to a connector. A blood pump having a pump inlet is configured for fluidly connecting with the connector, while an oxygenator having an oxygenator inlet is configured for fluidly connecting with a pump outlet. An infusion cannula is configured for fluidly connecting with an oxygenator outlet for infusing oxygenated blood into a patient's bloodstream.

A cover member (36) that forms an end of a housing (26) of an oxygenator (10) has a recessed wall portion (88) recessed relative to a cover main body (74) further toward a side of a gas exchange unit (30) than an inner surface (74a). A pressure control hole (86) is formed through a main body (74) of the cover member (36), and a sampling port (90a) is disposed in the second recessed wall portion (88) to collect gas guided out from the gas exchange unit (30). The sampling port (90a) faces, at its inner opening portion (92), a second outlet side end face (31b) of the gas exchange unit (30).

A sensor system for measuring oxygen saturation in blood flowing within a neonatal extracorporeal support system (NESS) includes a light source configured to emit a light wave, a light sensor configured to sense a light wave, a control unit, and an alarm. The control unit includes a processor operably coupled to at least one memory having instructions stored therein that, upon execution by the control unit, cause the sensor system to perform operations including emitting at least one light wave from the light source onto blood flowing within the NESS, receiving a reflected light wave from the light source onto blood flowing within the NESS, and comparing a parameter of the reflected light wave to a parameter of the at least one light wave to determine the oxygen saturation in the blood of the NESS. The blood flowing within the NESS is unaltered by the sensor system.